Latest News for: repressor

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2021 EHA Poster - A Phase 1a/b Dose Escalation Study of the MYC Repressor APTO-253 in R/R AML or HR MDS (Aptose Biosciences Inc)

Public Technologies 11 Jun 2021
). A Phase 1a/b Dose Escalation Study of the MYC Repressor APTO-253 in Patients with. Relapsed or Refractory AML or High-Risk MDS ... EHA2021 Abstract# EP452 ... INTRODUCTION ... Following infusion into patients, a fraction of APTO-253 binds iron and transforms to the Fe(253)3 conjugate which retains full activity ... Patient Demographics. Patient Demographics ... Male.
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Neo-Sultan of Turkey is the top journalist repressor

Blitz 09 Apr 2021
Turkey jails more journalists than any other country in the world ... ....
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Horizon Discovery Extends Gene Modulation Portfolio with Industry First Synthetic Single Guide RNA and Patent Pending dCas9 Repressor for CRISPR Interference (PerkinElmer Inc)

Public Technologies 29 Mar 2021
The new reagents include the first-ever commercially available synthetic single guide RNAs for CRISPRi, as well as a patent-pending, dCas9-SALL1-SDS3 repressor available in mRNA and lentiviral formats ... The novel dCas9-SALL1-SDS3 repressor was developed following extensive research ...
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2020 ASH Poster - A Phase 1a/b Dose Escalation Study of the MYC Repressor APTO-253 in Patients with R/R AML or HR-MDS (Aptose Biosciences Inc)

Public Technologies 05 Dec 2020
). A Phase 1a/b Dose Escalation Study of the MYC Repressor APTO-253. in Patients with Relapsed or Refractory AML or Higher-risk MDS. Presented by. Rafael Bejar1,2. Authors.. Rafael Bejar1,2. Hongying Zhang1. Nasrin Rastgoo1. Khalid Benbatoul1. Yuying Jin1. Mathew Thayer1. Susan Sheng1 ... APTO-253, a Unique Small Molecule Repressor of MYC in Clinical Development.
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Pits and CtBP Control Tissue Growth in Drosophila melanogaster with the Hippo Pathway Transcription Repressor ...

Genetics 05 May 2020
The Hippo pathway is an evolutionarily conserved signaling network that regulates organ size, cell fate, and tumorigenesis ... When it is not activated by Yorkie, Scalloped can act as a repressor of transcription, at least in part due to its interaction with the corepressor protein Tgi ... .
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Pits and CtBP Control Tissue Growth in Drosophila melanogaster with the Hippo Pathway Transcription Repressor, ...

Genetics 03 Mar 2020
The Hippo pathway is an evolutionary conserved signalling network that regulates organ size, cell fate control and tumorigenesis ... When it is not activated by Yorkie, Scalloped can act as a repressor of transcription, at least in part due to its interaction with the corepressor protein Tgi ... .
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Syros Presents on Identification of Novel Fetal Hemoglobin Repressor as Part of Broader Drug Discovery Program in Sickle Cell Disease at 61st Annual ASH Meeting

Public Technologies 08 Dec 2019
CAMBRIDGE, Mass.--(BUSINESS WIRE)-- Syros Pharmaceuticals (NASDAQ.SYRS), a leader in the development of medicines that control the expression of genes, today announced that it has discovered and validated a novel fetal hemoglobin repressor, Nuclear Factor I X (NFIX), using its gene control platform.
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In Saudi Arabia, Twitter becomes more useful to the repressors than the repressed

The Washington Post 16 Nov 2019
The targeting of Omar Abdulaziz shows how Twitter can be misused to stamp out dissent ... .
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Mutational inactivation of mTORC1 repressor gene DEPDC5 in human gastrointestinal stromal tumors [Medical Sciences]

PNAS 05 Nov 2019
Gastrointestinal stromal tumors (GISTs) are the most common human sarcoma and are initiated by activating mutations in the KIT or PDGFRA receptor tyrosine kinases. Chromosome 22q deletions are well-recognized frequent abnormalities in GISTs, occurring in ∼50% of GISTs. These deletions are thought to contribute to the pathogenesis of this disease... .
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