Pleurodesis is a medical procedure in which the pleural space is artificially obliterated.^[1] It involves the adhesion of the two pleurae.

Uses[link]

Pleurodesis is done to prevent recurrence of pneumothorax or recurrent pleural effusion. It can be done chemically or surgically.

Chemical[link]

Chemicals such as bleomycin, tetracycline, povidone iodine, or a slurry of talc can be introduced into the pleural space through a chest drain. The instilled chemicals cause irritation between the parietal and the visceral layers of the pleura which closes off the space between them and prevents further fluid from accumulating.^[2]

Povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost.^[3]

Chemical pleurodesis is a painful procedure, so patients are often premedicated with a sedative and analgesics. A local anesthetic may be instilled into the pleural space, or an epidural catheter may be placed for anesthesia.

Surgical[link]

Surgical pleurodesis is performed via thoracotomy or thoracoscopy. This involves mechanically irritating the parietal pleura, often with a rough pad. Moreover, surgical removal of parietal pleura is an effective way of achieving stable pleurodesis.

References[link]