The Indios de Mayagüez (English: Mayagüez Indians) are a baseball team in the Puerto Rican Professional Baseball League (PRBL, or LBPPR in Spanish). Based in Mayagüez, the Indios have won 17 national championships and two Caribbean World Series. It is one of four teams remaining from the original six incorporated into the LBPPR at its founding in 1938. Just won the PRBL Championship defeating Caguas Criollos 5 to 2 at Estadio Isidoro Cholo Garcia in Mayaguez, 1/25/2012, their number 17 making the team the winningest team in the league's history.

The Indios were named after the formerly named Cervecería India (now the Compañía Cervecera de Puerto Rico, or CCC), the local brewery, and its formal sponsor over most of the team's 74-year run) besides the fact that Mayagüez, located at the western coast of Puerto Rico, has a strong indigenous heritage, starting with the city's name (which is derived from the Taíno language). The team's colors are burgundy, red and gold, which at one time were the colors on the label of Cerveza India, the original flagship product of the brewery which promoted the team and served as base for its name. The CCC's current flagship product, Cerveza Medalla Light, is now the team's official endorser.