Elfazepam

Elfazepam is a drug which is a benzodiazepine derivative. Presumably it has sedative and anxiolytic actions like those of other benzodiazepines.

It has appetite stimulating properties in animals. The mechanism for increasing feed intake is not clear and has been subject of investigation. It has been found that elfazepam suppresses gastric acid secretion.

Synthesis

Benzophenone derivative 1 is reacted with a glycine equvalent masked as an oxazolidine-2,5-dione.

References

↑ U.S. Patent 4,010,154

↑ Psychotropics.dk

↑ Baile, CA.; McLaughlin, CL. (Nov 1979). "A review of the behavioral and physiological responses to elfazepam, a chemical feed intake stimulant.". J Anim Sci 49 (5): 1371–95. PMID 396294.

↑ Baile, CA.; Naylor, J.; McLaughlin, CL.; Catanzaro, CA. (Aug 1981). "Endotoxin-elicited fever and anorexia and elfazepam-stimulated feeding in sheep.". Physiol Behav 27 (2): 271–7. doi:10.1016/0031-9384(81)90269-9. PMID 7029576.

↑ Keim, DA.; Baile, CA.; Bolton, JR.; Wangsness, PJ.; Della Fera, MA. (Jan 1979). "Abomasal function following injections of elfazepam and 9-aza-cannabinol.". Pharmacol Biochem Behav 10 (1): 63–70. doi:10.1016/0091-3057(79)90170-9. PMID 35793.

This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Elfazepam

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Elfazepam

Synthesis

References

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