Ploče (pronounced [plɔ̂tʃɛ]; Italian: Porto Tòlero) is a town and a notable seaport in the Dubrovnik-Neretva County of Croatia.

Ploče is located on the Adriatic coast in Dalmatia just north of the Neretva Delta and is as such the natural seaside endpoint of most north-south routes through the central Dinaric Alps. This makes it the primary seaport used by Bosnia and Herzegovina and the endpoint of the Pan-European corridor 5C.

Čeveljuša is a toponym in Ploče, located to the east of the town, on the intersection of the D8 highway and the D425.

Ploče was named Kardeljevo after the Yugoslav politician Edvard Kardelj between 1950 and 1954 and again between 1980 and 1990.

The locals call their city Ploča.

The total population of Ploče is 10,102 (2011), in the following settlements:

In the 2001 census, the majority of its citizens were Croats at 95.12%.

The Port of Ploče was first mentioned on 6 November 1387, but the building of a larger port was done in recent modern times. Work on the present day harbour first began in 1939 but was destroyed during World War II. It was rebuilt in 1945 and the village of Ploče grew up to 480 inhabitants in 1948. After the Adriatic road and Neretva railway lines were built to the port in the mid-1960s, the town experienced a steady growth.