NEU1
Sialidase 1 (lysosomal sialidase), also known as NEU1 is a mammalian lysosomal neuraminidase enzyme which in humans is encoded by the NEU1 gene.
Function
The protein encoded by this gene encodes the lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis.
Clinical significance
Deficiencies in the human enzyme NEU1 leads to sialidosis, a rare lysosomal storage disease. Sialidase has also been shown to enhance recovery from spinal cord contusion injury when injected in rats.
Interactions
NEU1 has been shown to interact with Cathepsin A.
References
Further reading
Don't Call Me
Verse 1: I became her lover, she became my lover. Had her heart broke, I was helping her recover. I became the man she knew she could rely on. Somebody to listen or shoulder to cry on. She was getting better, better she was getting. The more time spent, the more she would forget him. But then back around he seen that he started coming, and shes on the low taking phone calls from him. I thought that we were building something strong. He apologizes and now your gone. And I won't put up with this.
Pre-chorus: You wanna go. (Go.) Just hope you know. Baby your gonna be lonely, lonely again. Oh lonely, lonely. Go on go, go. Just hope you know. (Hey.) Baby your gonna be lonely, lonely again. Lonely, lonely again.
Chorus: Don't call me when your lonely again. When your lonely again, lonely again. Oh, sugga don't call me when your lonely again, when your lonely again. Lonely again. (Oh.)