The Highway of Death refers to a six-lane highway between Kuwait and Iraq, officially known as Highway 80. It runs from Kuwait City to the border town of Safwan and then on to Basra.

During the United Nations coalition offensive in the Gulf War, retreating Iraqi military personnel and others escaping Kuwait were attacked on Highway 80 by American aircraft and ground forces on the night of February 26–27, 1991, resulting in the destruction of hundreds of vehicles and the deaths of many of their occupants. The scenes of devastation on the road are some of the most recognizable images of the war, and were publicly cited as a factor in President George H. W. Bush's decision to declare a cessation of hostilities on the next day. Many Iraqi forces however successfully escaped across the Euphrates river and the U.S. Defense Intelligence Agency estimated that upwards of 70,000 to 80,000 troops from defeated divisions in Kuwait might have fled into the city of Basra.

The road was repaired during the late 1990s, and was used in the initial stages of the 2003 invasion of Iraq by U.S. and British forces, and previously it had been also used during the 1990 Invasion of Kuwait by the Iraqi armored divisions.