Isoleucine (abbreviated as Ile or I) is an α-amino acid with the chemical formula HO2CCH(NH2)CH(CH3)CH2CH3. It is an essential amino acid, which means that humans cannot synthesize it, so it must be ingested. Its codons are AUU, AUC and AUA.
With a hydrocarbon side chain, isoleucine is classified as a hydrophobic amino acid. Together with threonine, isoleucine is one of two common amino acids that have a chiral side chain. Four stereoisomers of isoleucine are possible, including two possible diastereomers of L-isoleucine. However, isoleucine present in nature exists in one enantiomeric form, (2S,3S)-2-amino-3-methylpentanoic acid.
As an essential amino acid, isoleucine is not synthesized in animals, hence it must be ingested, usually as a component of proteins. In plants and microorganisms, it is synthesized via several steps, starting from pyruvic acid and alpha-ketoglutarate. Enzymes involved in this biosynthesis include:
Isoleucine is both a glucogenic and a ketogenic amino acid. After transamination with alpha-ketoglutarate the carbon skeleton can be converted into either Succinyl CoA, and fed into the TCA cycle for oxidation or conversion into oxaloacetate for gluconeogenesis (hence glucogenic). It can also be converted into Acetyl CoA and fed into the TCA cycle by condensing with oxaloacetate to form citrate. In mammals Acetyl CoA cannot be converted back to carbohydrate but can be used in the synthesis of ketone bodies or fatty acids, hence ketogenic.
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isoleucine
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What Are BCAA's And How Do They Work?
isoleucine
BCAA's are one of the best supplements you can take...
الموسوعة الغذائية - إل آيزولوسين - L-Isoleucine
How to Pronounce Isoleucine
How to pronounce Isoleucine
Valine-Leucine-IsoLeucine-SchroederDiamonds9SEP11
Isoleucine PROLINE Lysine histidine C-STARmemLAST-III-JUN2010
IsoLeucine Ile Threonine Thr Essential Amino Acids 27SEP10
Biochemistry: Amino acids: 05 Isoleucine
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Cable Cross Over - Amanda Latona Turning Heads S1 EP8
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I do not mean to be so rude
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