- published: 14 Dec 2012
- views: 132431
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http://www.handwrittentutorials.com - This tutorial is the fourth in the Pharmacokinetics series. This tutorial discusses how drugs are metabolised by Cytochrome P450 enzymes. This tutorial covers Phase 1 and Phase 2 metabolism and gives a real world example. For more entirely FREE tutorials and the accompanying PDFs visit http://www.handwrittentutorials.com
1.IN DEPTH ANALYSIS OF aiims, aipgmee, aipg,fmgeQUESTION PAPERS.
2.SUBJECT WISE AND TOPIC WISE DISCUSSION ON IMPORTANT AND FREQUENTLY ASKED QUESTIONS
3.EACH NOTES DURATION IS 2 TO 3 MINUTES.
Complex concepts explained
Fun introduced to dry topics
A fast paced online course,designed for medical students.
visit www.fmgsindia.com and join crack fmge program.
· Complete exam preparation material for medical students.
· More than 1000 mock tests.
· Exam-style practice questions with e-books,videos etc.
· More than 100,000 exam-like questions | free integrated mobile app for Android™.
· Prepare fmge exams with ease.
· Clinical Correlates: Short, comprehensive video lectures designed to integrate knowledge of the basic sciences to clinical applications and context
· Start now and get an immediate edge in repeat questions and frequently tested topics as often as you like for the next 6 months.
-~-~~-~~~-~~-~-
Please watch: "Bevacizumab quick review -anticancer drugs-pharmacology"
→ https://www.youtube.com/watch?v=-JICcTfJ7hU
-~-~~-~~~-~~-~-
- published: 25 Nov 2015
- views: 3020
http://usmlefasttrack.com/?p=5058 modafinil, barbiturates, st johns wort, phenytoin, rifampin, griseofulvin, carbamazepine, chronic alcohol use, macrolides, amiodarone, grapefruit juice, isoniazid, cimetidine, ritonavir, acute alcohol abuse, ciprofloxacin, ketoconazole, sulfonamides, gemfibrozil, quinidine, mnemonics: momma barb steals phen-phen and refuses greasy carbs chronically, magic racks in GQ Cytochrome, p450, Inducers, and, Inhibitors, , Findings, symptoms, findings, causes, mnemonics, review, what is, video, study, Rapid Review, Clinical presenation, First Aid, for, USMLE, Step 1, images, wiki, define, wikipedia, 2013, videos, exam, prep, easy, What is usmle, mnemonic, causes,
- published: 23 Oct 2013
- views: 14058
Cytochrome P450 enzymes catalyze the oxidation of organic compounds through radical intermediates. This webcast describes the mechanism of oxidation and how we can use principles of radical stability to correctly predict preferred sites of oxidation.
Check out this page for more information about the degradation of nicotine by Cyt P450:
https://wiki.cites.uiuc.edu/wiki/display/MetabolicPathways/cytochrome+P450+2A6
- published: 29 Dec 2010
- views: 24480
Looking at the biochemistry of how cytochrome p 450 enzymes work.
- published: 20 Mar 2014
- views: 6178
Drug Metabolism - Phase 1
A video overview of Phase I metabolism & cytochrome P450 system (CYP450, P450). View the rest of my pharmacology videos in order below:
(1) Pharmacokinetics & ADME: http://youtu.be/CMRZqdrkCZw
DRUG ABSORPTION Videos:
(2) Drug Absorption Overview: http://youtu.be/eya9jR3v7i8
(3) Bioavailability: http://youtu.be/rv2Rpdi7OHM
DRUG DISTRIBUTION Videos:
(4) Drug Distribution Overview: http://youtu.be/DH2WGUd7MBs
(5) Volume of Distribution: http://youtu.be/B63sqUfvFQQ
------------------
DRUG METABOLISM Videos:
(6) First Pass Metabolism: http://youtu.be/5AB8WkCbz4k
(7) Phase I Metabolism: http://youtu.be/GGLddVpVg9M
(8) Phase II Metabolism: http://youtu.be/iIWAUo05GFE
(9) First Order and Zero Order Kinetics: http://youtu.be/XEotDfKhNTw
(10) Drug Half-life: http://youtu.be/eTqPsqnbwoc
(11) First-order elimination rate constant and half-life-details: http://youtu.be/De9999Jj-5Q
------------------------------------------
DRUG ELIMINATION / EXCRETION
(12) Drug Clearance: http://youtu.be/csywV3MYHDg
(13) Renal Excretion of Drugs: http://youtu.be/8c3gqI6R-Vw
(14) Ion Trapping: [not yet posted]
(15) Dosage Regimens: [not yet posted]
---------------------------------------------------------------------
Factors That Affect Drug Metabolism:
(16) Enzyme Induction: http://youtu.be/Dtbkc8F_ff0
(17) Competitive Inhibition Overview: http://youtu.be/iNIxMuHuL3w
(18) Competitive Inhibition of Statins: http://youtu.be/Lt1-mjMFniE
(19) Acetaminophen toxicity (Clinical Correlate): [Not yet posted]
(20) Pharmacogenomics Overview: http://youtu.be/3vZxbX5P9TU
(21) Slow Acetylators - Pharmacogenomics: [not yet posted]
Help us caption & translate this video!
http://amara.org/v/B5En/
- published: 20 Sep 2012
- views: 80366
Video to supplement the written assignment:
References:
Guengerich, P. (2001). Chapter two, Cytochrome P450. Enzyme Systems that Metabolise Drugs and Other Xenobiotics. John Wiley & Sons Ltd.
Marieb, E. (1998) Human Anatomy & Physiology 4th Edition. Benjamin Cummings. Menlo Park, California.
University of Calgary. (2015). Lecture 25, Homonuclear Diatomic Molecules II. Retrieved on January 6, 2015 from http://www.cobalt.chem.ucalgary.ca/ziegler/Lec.chm373/lec27/Lecture27.pdf
University of Florida. (2015). Module two notes. Retrieved on January 6, 2015 from https://lss.at.ufl.edu/
- published: 17 Jan 2015
- views: 2136
Cytochrome P450
Cytochromes P450 (CYPs) belong to the superfamily of proteins containing a heme cofactor and, therefore, are hemoproteins. CYPs use a variety of small and large molecules as substrates in enzymatic reactions. They are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term P450 is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with CO.
CYP enzymes have been identified in all domains of life - animals, plants, fungi, protists, bacteria, archaea, and even in viruses. However, the enzymes have not been found in E. coli. More than 21,000 distinct CYP proteins are known.
Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen). Based on the nature of the electron transfer proteins, CYPs can be classified into several groups:
This page contains text from Wikipedia, the Free Encyclopedia -
http://wn.com/Cytochrome_P450
This article is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License, which means that you can copy and modify it as long as the entire work (including additions) remains under this license.
This article is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License, which means that you can copy and modify it as long as the entire work (including additions) remains under this license.
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5:20Pharmacokinetics 4 - Metabolism
Pharmacokinetics 4 - MetabolismPharmacokinetics 4 - Metabolism
http://www.handwrittentutorials.com - This tutorial is the fourth in the Pharmacokinetics series. This tutorial discusses how drugs are metabolised by Cytochrome P450 enzymes. This tutorial covers Phase 1 and Phase 2 metabolism and gives a real world example. For more entirely FREE tutorials and the accompanying PDFs visit http://www.handwrittentutorials.com -
1:43Cytochrome p450 inhibitors and inducers
Cytochrome p450 inhibitors and inducersCytochrome p450 inhibitors and inducers
1.IN DEPTH ANALYSIS OF aiims, aipgmee, aipg,fmgeQUESTION PAPERS. 2.SUBJECT WISE AND TOPIC WISE DISCUSSION ON IMPORTANT AND FREQUENTLY ASKED QUESTIONS 3.EACH NOTES DURATION IS 2 TO 3 MINUTES. Complex concepts explained Fun introduced to dry topics A fast paced online course,designed for medical students. visit www.fmgsindia.com and join crack fmge program. · Complete exam preparation material for medical students. · More than 1000 mock tests. · Exam-style practice questions with e-books,videos etc. · More than 100,000 exam-like questions | free integrated mobile app for Android™. · Prepare fmge exams with ease. · Clinical Correlates: Short, comprehensive video lectures designed to integrate knowledge of the basic sciences to clinical applications and context · Start now and get an immediate edge in repeat questions and frequently tested topics as often as you like for the next 6 months. -~-~~-~~~-~~-~- Please watch: "Bevacizumab quick review -anticancer drugs-pharmacology" → https://www.youtube.com/watch?v=-JICcTfJ7hU -~-~~-~~~-~~-~- -
2:31Cytochrome p450 Inducers and Inhibitors
Cytochrome p450 Inducers and InhibitorsCytochrome p450 Inducers and Inhibitors
http://usmlefasttrack.com/?p=5058 modafinil, barbiturates, st johns wort, phenytoin, rifampin, griseofulvin, carbamazepine, chronic alcohol use, macrolides, amiodarone, grapefruit juice, isoniazid, cimetidine, ritonavir, acute alcohol abuse, ciprofloxacin, ketoconazole, sulfonamides, gemfibrozil, quinidine, mnemonics: momma barb steals phen-phen and refuses greasy carbs chronically, magic racks in GQ Cytochrome, p450, Inducers, and, Inhibitors, , Findings, symptoms, findings, causes, mnemonics, review, what is, video, study, Rapid Review, Clinical presenation, First Aid, for, USMLE, Step 1, images, wiki, define, wikipedia, 2013, videos, exam, prep, easy, What is usmle, mnemonic, causes, -
2:17Cytochrome P450: Radicals in a Biochemical Setting
Cytochrome P450: Radicals in a Biochemical SettingCytochrome P450: Radicals in a Biochemical Setting
Cytochrome P450 enzymes catalyze the oxidation of organic compounds through radical intermediates. This webcast describes the mechanism of oxidation and how we can use principles of radical stability to correctly predict preferred sites of oxidation. Check out this page for more information about the degradation of nicotine by Cyt P450: https://wiki.cites.uiuc.edu/wiki/display/MetabolicPathways/cytochrome+P450+2A6 -
15:32Cytochrome P450 1
Cytochrome P450 1Cytochrome P450 1
-
18:33Cytochrome P450 Catalytic Cycle
Cytochrome P450 Catalytic CycleCytochrome P450 Catalytic Cycle
-
1:13Cytochrome P450 - Tales from the Genome
Cytochrome P450 - Tales from the Genome -
18:14Biochemistry of cytochrome P 450 enzymes
Biochemistry of cytochrome P 450 enzymesBiochemistry of cytochrome P 450 enzymes
Looking at the biochemistry of how cytochrome p 450 enzymes work. -
6:56Phase I Metabolism - Pharmacology Lect 7
Phase I Metabolism - Pharmacology Lect 7Phase I Metabolism - Pharmacology Lect 7
Drug Metabolism - Phase 1 A video overview of Phase I metabolism & cytochrome P450 system (CYP450, P450). View the rest of my pharmacology videos in order below: (1) Pharmacokinetics & ADME: http://youtu.be/CMRZqdrkCZw DRUG ABSORPTION Videos: (2) Drug Absorption Overview: http://youtu.be/eya9jR3v7i8 (3) Bioavailability: http://youtu.be/rv2Rpdi7OHM DRUG DISTRIBUTION Videos: (4) Drug Distribution Overview: http://youtu.be/DH2WGUd7MBs (5) Volume of Distribution: http://youtu.be/B63sqUfvFQQ ------------------ DRUG METABOLISM Videos: (6) First Pass Metabolism: http://youtu.be/5AB8WkCbz4k (7) Phase I Metabolism: http://youtu.be/GGLddVpVg9M (8) Phase II Metabolism: http://youtu.be/iIWAUo05GFE (9) First Order and Zero Order Kinetics: http://youtu.be/XEotDfKhNTw (10) Drug Half-life: http://youtu.be/eTqPsqnbwoc (11) First-order elimination rate constant and half-life-details: http://youtu.be/De9999Jj-5Q ------------------------------------------ DRUG ELIMINATION / EXCRETION (12) Drug Clearance: http://youtu.be/csywV3MYHDg (13) Renal Excretion of Drugs: http://youtu.be/8c3gqI6R-Vw (14) Ion Trapping: [not yet posted] (15) Dosage Regimens: [not yet posted] --------------------------------------------------------------------- Factors That Affect Drug Metabolism: (16) Enzyme Induction: http://youtu.be/Dtbkc8F_ff0 (17) Competitive Inhibition Overview: http://youtu.be/iNIxMuHuL3w (18) Competitive Inhibition of Statins: http://youtu.be/Lt1-mjMFniE (19) Acetaminophen toxicity (Clinical Correlate): [Not yet posted] (20) Pharmacogenomics Overview: http://youtu.be/3vZxbX5P9TU (21) Slow Acetylators - Pharmacogenomics: [not yet posted] Help us caption & translate this video! http://amara.org/v/B5En/ -
28:55Cytochrome P450 oxidase enzyme function and co-factors/enzymes
Cytochrome P450 oxidase enzyme function and co-factors/enzymesCytochrome P450 oxidase enzyme function and co-factors/enzymes
Video to supplement the written assignment: References: Guengerich, P. (2001). Chapter two, Cytochrome P450. Enzyme Systems that Metabolise Drugs and Other Xenobiotics. John Wiley & Sons Ltd. Marieb, E. (1998) Human Anatomy & Physiology 4th Edition. Benjamin Cummings. Menlo Park, California. University of Calgary. (2015). Lecture 25, Homonuclear Diatomic Molecules II. Retrieved on January 6, 2015 from http://www.cobalt.chem.ucalgary.ca/ziegler/Lec.chm373/lec27/Lecture27.pdf University of Florida. (2015). Module two notes. Retrieved on January 6, 2015 from https://lss.at.ufl.edu/
-
Pharmacokinetics 4 - Metabolism
http://www.handwrittentutorials.com - This tutorial is the fourth in the Pharmacokinetics series. This tutorial discusses how drugs are metabolised by Cytochrome P450 enzymes. This tutorial covers Phase 1 and Phase 2 metabolism and gives a real world example. For more entirely FREE tutorials and the accompanying PDFs visit http://www.handwrittentutorials.com -
Cytochrome p450 inhibitors and inducers
1.IN DEPTH ANALYSIS OF aiims, aipgmee, aipg,fmgeQUESTION PAPERS. 2.SUBJECT WISE AND TOPIC WISE DISCUSSION ON IMPORTANT AND FREQUENTLY ASKED QUESTIONS 3.EACH NOTES DURATION IS 2 TO 3 MINUTES. Complex concepts explained Fun introduced to dry topics A fast paced online course,designed for medical students. visit www.fmgsindia.com and join crack fmge program. · Complete exam preparation material for medical students. · More than 1000 mock tests. · Exam-style practice questions with e-books,videos etc. · More than 100,000 exam-like questions | free integrated mobile app for Android™. · Prepare fmge exams with ease. · Clinical Correlates: Short, comprehensive video lectures designed to integrate knowledge of the basic sciences to clinical applications and context · Start now and get an i... -
Cytochrome p450 Inducers and Inhibitors
http://usmlefasttrack.com/?p=5058 modafinil, barbiturates, st johns wort, phenytoin, rifampin, griseofulvin, carbamazepine, chronic alcohol use, macrolides, amiodarone, grapefruit juice, isoniazid, cimetidine, ritonavir, acute alcohol abuse, ciprofloxacin, ketoconazole, sulfonamides, gemfibrozil, quinidine, mnemonics: momma barb steals phen-phen and refuses greasy carbs chronically, magic racks in GQ Cytochrome, p450, Inducers, and, Inhibitors, , Findings, symptoms, findings, causes, mnemonics, review, what is, video, study, Rapid Review, Clinical presenation, First Aid, for, USMLE, Step 1, images, wiki, define, wikipedia, 2013, videos, exam, prep, easy, What is usmle, mnemonic, causes, -
Cytochrome P450: Radicals in a Biochemical Setting
Cytochrome P450 enzymes catalyze the oxidation of organic compounds through radical intermediates. This webcast describes the mechanism of oxidation and how we can use principles of radical stability to correctly predict preferred sites of oxidation. Check out this page for more information about the degradation of nicotine by Cyt P450: https://wiki.cites.uiuc.edu/wiki/display/MetabolicPathways/cytochrome+P450+2A6 -
Cytochrome P450 1
-
Cytochrome P450 Catalytic Cycle
-
-
Biochemistry of cytochrome P 450 enzymes
Looking at the biochemistry of how cytochrome p 450 enzymes work. -
Phase I Metabolism - Pharmacology Lect 7
Drug Metabolism - Phase 1 A video overview of Phase I metabolism & cytochrome P450 system (CYP450, P450). View the rest of my pharmacology videos in order below: (1) Pharmacokinetics & ADME: http://youtu.be/CMRZqdrkCZw DRUG ABSORPTION Videos: (2) Drug Absorption Overview: http://youtu.be/eya9jR3v7i8 (3) Bioavailability: http://youtu.be/rv2Rpdi7OHM DRUG DISTRIBUTION Videos: (4) Drug Distribution Overview: http://youtu.be/DH2WGUd7MBs (5) Volume of Distribution: http://youtu.be/B63sqUfvFQQ ------------------ DRUG METABOLISM Videos: (6) First Pass Metabolism: http://youtu.be/5AB8WkCbz4k (7) Phase I Metabolism: http://youtu.be/GGLddVpVg9M (8) Phase II Metabolism: http://youtu.be/iIWAUo05GFE (9) First Order and Zero Order Kinetics: http://youtu.be/XEotDfKhNTw (10) Drug Half-life: http://youtu.... -
Cytochrome P450 oxidase enzyme function and co-factors/enzymes
Video to supplement the written assignment: References: Guengerich, P. (2001). Chapter two, Cytochrome P450. Enzyme Systems that Metabolise Drugs and Other Xenobiotics. John Wiley & Sons Ltd. Marieb, E. (1998) Human Anatomy & Physiology 4th Edition. Benjamin Cummings. Menlo Park, California. University of Calgary. (2015). Lecture 25, Homonuclear Diatomic Molecules II. Retrieved on January 6, 2015 from http://www.cobalt.chem.ucalgary.ca/ziegler/Lec.chm373/lec27/Lecture27.pdf University of Florida. (2015). Module two notes. Retrieved on January 6, 2015 from https://lss.at.ufl.edu/
Pharmacokinetics 4 - Metabolism
- Order: Reorder
- Duration: 5:20
- Updated: 14 Dec 2012
- views: 132431
http://www.handwrittentutorials.com - This tutorial is the fourth in the Pharmacokinetics series. This tutorial discusses how drugs are metabolised by Cytochrom...
http://www.handwrittentutorials.com - This tutorial is the fourth in the Pharmacokinetics series. This tutorial discusses how drugs are metabolised by Cytochrome P450 enzymes. This tutorial covers Phase 1 and Phase 2 metabolism and gives a real world example. For more entirely FREE tutorials and the accompanying PDFs visit http://www.handwrittentutorials.com
wn.com/Pharmacokinetics 4 Metabolism
http://www.handwrittentutorials.com - This tutorial is the fourth in the Pharmacokinetics series. This tutorial discusses how drugs are metabolised by Cytochrome P450 enzymes. This tutorial covers Phase 1 and Phase 2 metabolism and gives a real world example. For more entirely FREE tutorials and the accompanying PDFs visit http://www.handwrittentutorials.com
- published: 14 Dec 2012
- views: 132431
Cytochrome p450 inhibitors and inducers
- Order: Reorder
- Duration: 1:43
- Updated: 25 Nov 2015
- views: 3020
1.IN DEPTH ANALYSIS OF aiims, aipgmee, aipg,fmgeQUESTION PAPERS.
2.SUBJECT WISE AND TOPIC WISE DISCUSSION ON IMPORTANT AND FREQUENTLY ASKED QUESTIONS
3.EACH NO...
1.IN DEPTH ANALYSIS OF aiims, aipgmee, aipg,fmgeQUESTION PAPERS.
2.SUBJECT WISE AND TOPIC WISE DISCUSSION ON IMPORTANT AND FREQUENTLY ASKED QUESTIONS
3.EACH NOTES DURATION IS 2 TO 3 MINUTES.
Complex concepts explained
Fun introduced to dry topics
A fast paced online course,designed for medical students.
visit www.fmgsindia.com and join crack fmge program.
· Complete exam preparation material for medical students.
· More than 1000 mock tests.
· Exam-style practice questions with e-books,videos etc.
· More than 100,000 exam-like questions | free integrated mobile app for Android™.
· Prepare fmge exams with ease.
· Clinical Correlates: Short, comprehensive video lectures designed to integrate knowledge of the basic sciences to clinical applications and context
· Start now and get an immediate edge in repeat questions and frequently tested topics as often as you like for the next 6 months.
-~-~~-~~~-~~-~-
Please watch: "Bevacizumab quick review -anticancer drugs-pharmacology"
→ https://www.youtube.com/watch?v=-JICcTfJ7hU
-~-~~-~~~-~~-~-
wn.com/Cytochrome P450 Inhibitors And Inducers
1.IN DEPTH ANALYSIS OF aiims, aipgmee, aipg,fmgeQUESTION PAPERS.
2.SUBJECT WISE AND TOPIC WISE DISCUSSION ON IMPORTANT AND FREQUENTLY ASKED QUESTIONS
3.EACH NOTES DURATION IS 2 TO 3 MINUTES.
Complex concepts explained
Fun introduced to dry topics
A fast paced online course,designed for medical students.
visit www.fmgsindia.com and join crack fmge program.
· Complete exam preparation material for medical students.
· More than 1000 mock tests.
· Exam-style practice questions with e-books,videos etc.
· More than 100,000 exam-like questions | free integrated mobile app for Android™.
· Prepare fmge exams with ease.
· Clinical Correlates: Short, comprehensive video lectures designed to integrate knowledge of the basic sciences to clinical applications and context
· Start now and get an immediate edge in repeat questions and frequently tested topics as often as you like for the next 6 months.
-~-~~-~~~-~~-~-
Please watch: "Bevacizumab quick review -anticancer drugs-pharmacology"
→ https://www.youtube.com/watch?v=-JICcTfJ7hU
-~-~~-~~~-~~-~-
- published: 25 Nov 2015
- views: 3020
Cytochrome p450 Inducers and Inhibitors
- Order: Reorder
- Duration: 2:31
- Updated: 23 Oct 2013
- views: 14058
http://usmlefasttrack.com/?p=5058 modafinil, barbiturates, st johns wort, phenytoin, rifampin, griseofulvin, carbamazepine, chronic alcohol use, macrolides, am...
http://usmlefasttrack.com/?p=5058 modafinil, barbiturates, st johns wort, phenytoin, rifampin, griseofulvin, carbamazepine, chronic alcohol use, macrolides, amiodarone, grapefruit juice, isoniazid, cimetidine, ritonavir, acute alcohol abuse, ciprofloxacin, ketoconazole, sulfonamides, gemfibrozil, quinidine, mnemonics: momma barb steals phen-phen and refuses greasy carbs chronically, magic racks in GQ Cytochrome, p450, Inducers, and, Inhibitors, , Findings, symptoms, findings, causes, mnemonics, review, what is, video, study, Rapid Review, Clinical presenation, First Aid, for, USMLE, Step 1, images, wiki, define, wikipedia, 2013, videos, exam, prep, easy, What is usmle, mnemonic, causes,
wn.com/Cytochrome P450 Inducers And Inhibitors
http://usmlefasttrack.com/?p=5058 modafinil, barbiturates, st johns wort, phenytoin, rifampin, griseofulvin, carbamazepine, chronic alcohol use, macrolides, amiodarone, grapefruit juice, isoniazid, cimetidine, ritonavir, acute alcohol abuse, ciprofloxacin, ketoconazole, sulfonamides, gemfibrozil, quinidine, mnemonics: momma barb steals phen-phen and refuses greasy carbs chronically, magic racks in GQ Cytochrome, p450, Inducers, and, Inhibitors, , Findings, symptoms, findings, causes, mnemonics, review, what is, video, study, Rapid Review, Clinical presenation, First Aid, for, USMLE, Step 1, images, wiki, define, wikipedia, 2013, videos, exam, prep, easy, What is usmle, mnemonic, causes,
- published: 23 Oct 2013
- views: 14058
Cytochrome P450: Radicals in a Biochemical Setting
- Order: Reorder
- Duration: 2:17
- Updated: 29 Dec 2010
- views: 24480
Cytochrome P450 enzymes catalyze the oxidation of organic compounds through radical intermediates. This webcast describes the mechanism of oxidation and how we ...
Cytochrome P450 enzymes catalyze the oxidation of organic compounds through radical intermediates. This webcast describes the mechanism of oxidation and how we can use principles of radical stability to correctly predict preferred sites of oxidation.
Check out this page for more information about the degradation of nicotine by Cyt P450:
https://wiki.cites.uiuc.edu/wiki/display/MetabolicPathways/cytochrome+P450+2A6
wn.com/Cytochrome P450 Radicals In A Biochemical Setting
Cytochrome P450 enzymes catalyze the oxidation of organic compounds through radical intermediates. This webcast describes the mechanism of oxidation and how we can use principles of radical stability to correctly predict preferred sites of oxidation.
Check out this page for more information about the degradation of nicotine by Cyt P450:
https://wiki.cites.uiuc.edu/wiki/display/MetabolicPathways/cytochrome+P450+2A6
- published: 29 Dec 2010
- views: 24480
Cytochrome P450 1
- Order: Reorder
- Duration: 15:32
- Updated: 20 Aug 2014
- views: 9023
- published: 20 Aug 2014
- views: 9023
Cytochrome P450 Catalytic Cycle
- Order: Reorder
- Duration: 18:33
- Updated: 20 Aug 2014
- views: 6659
- published: 20 Aug 2014
- views: 6659
Cytochrome P450 - Tales from the Genome
- Order: Reorder
- Duration: 1:13
- Updated: 23 Feb 2015
- views: 769
This video is part of an online course, Tales from the Genome. Check out the course here: https://www.udacity.com/course/bio110.
This video is part of an online course, Tales from the Genome. Check out the course here: https://www.udacity.com/course/bio110.
wn.com/Cytochrome P450 Tales From The Genome
Biochemistry of cytochrome P 450 enzymes
- Order: Reorder
- Duration: 18:14
- Updated: 20 Mar 2014
- views: 6178
Looking at the biochemistry of how cytochrome p 450 enzymes work.
Looking at the biochemistry of how cytochrome p 450 enzymes work.
wn.com/Biochemistry Of Cytochrome P 450 Enzymes
Looking at the biochemistry of how cytochrome p 450 enzymes work.
- published: 20 Mar 2014
- views: 6178
Phase I Metabolism - Pharmacology Lect 7
- Order: Reorder
- Duration: 6:56
- Updated: 20 Sep 2012
- views: 80366
Drug Metabolism - Phase 1
A video overview of Phase I metabolism & cytochrome P450 system (CYP450, P450). View the rest of my pharmacology videos in order belo...
Drug Metabolism - Phase 1
A video overview of Phase I metabolism & cytochrome P450 system (CYP450, P450). View the rest of my pharmacology videos in order below:
(1) Pharmacokinetics & ADME: http://youtu.be/CMRZqdrkCZw
DRUG ABSORPTION Videos:
(2) Drug Absorption Overview: http://youtu.be/eya9jR3v7i8
(3) Bioavailability: http://youtu.be/rv2Rpdi7OHM
DRUG DISTRIBUTION Videos:
(4) Drug Distribution Overview: http://youtu.be/DH2WGUd7MBs
(5) Volume of Distribution: http://youtu.be/B63sqUfvFQQ
------------------
DRUG METABOLISM Videos:
(6) First Pass Metabolism: http://youtu.be/5AB8WkCbz4k
(7) Phase I Metabolism: http://youtu.be/GGLddVpVg9M
(8) Phase II Metabolism: http://youtu.be/iIWAUo05GFE
(9) First Order and Zero Order Kinetics: http://youtu.be/XEotDfKhNTw
(10) Drug Half-life: http://youtu.be/eTqPsqnbwoc
(11) First-order elimination rate constant and half-life-details: http://youtu.be/De9999Jj-5Q
------------------------------------------
DRUG ELIMINATION / EXCRETION
(12) Drug Clearance: http://youtu.be/csywV3MYHDg
(13) Renal Excretion of Drugs: http://youtu.be/8c3gqI6R-Vw
(14) Ion Trapping: [not yet posted]
(15) Dosage Regimens: [not yet posted]
---------------------------------------------------------------------
Factors That Affect Drug Metabolism:
(16) Enzyme Induction: http://youtu.be/Dtbkc8F_ff0
(17) Competitive Inhibition Overview: http://youtu.be/iNIxMuHuL3w
(18) Competitive Inhibition of Statins: http://youtu.be/Lt1-mjMFniE
(19) Acetaminophen toxicity (Clinical Correlate): [Not yet posted]
(20) Pharmacogenomics Overview: http://youtu.be/3vZxbX5P9TU
(21) Slow Acetylators - Pharmacogenomics: [not yet posted]
Help us caption & translate this video!
http://amara.org/v/B5En/
wn.com/Phase I Metabolism Pharmacology Lect 7
Drug Metabolism - Phase 1
A video overview of Phase I metabolism & cytochrome P450 system (CYP450, P450). View the rest of my pharmacology videos in order below:
(1) Pharmacokinetics & ADME: http://youtu.be/CMRZqdrkCZw
DRUG ABSORPTION Videos:
(2) Drug Absorption Overview: http://youtu.be/eya9jR3v7i8
(3) Bioavailability: http://youtu.be/rv2Rpdi7OHM
DRUG DISTRIBUTION Videos:
(4) Drug Distribution Overview: http://youtu.be/DH2WGUd7MBs
(5) Volume of Distribution: http://youtu.be/B63sqUfvFQQ
------------------
DRUG METABOLISM Videos:
(6) First Pass Metabolism: http://youtu.be/5AB8WkCbz4k
(7) Phase I Metabolism: http://youtu.be/GGLddVpVg9M
(8) Phase II Metabolism: http://youtu.be/iIWAUo05GFE
(9) First Order and Zero Order Kinetics: http://youtu.be/XEotDfKhNTw
(10) Drug Half-life: http://youtu.be/eTqPsqnbwoc
(11) First-order elimination rate constant and half-life-details: http://youtu.be/De9999Jj-5Q
------------------------------------------
DRUG ELIMINATION / EXCRETION
(12) Drug Clearance: http://youtu.be/csywV3MYHDg
(13) Renal Excretion of Drugs: http://youtu.be/8c3gqI6R-Vw
(14) Ion Trapping: [not yet posted]
(15) Dosage Regimens: [not yet posted]
---------------------------------------------------------------------
Factors That Affect Drug Metabolism:
(16) Enzyme Induction: http://youtu.be/Dtbkc8F_ff0
(17) Competitive Inhibition Overview: http://youtu.be/iNIxMuHuL3w
(18) Competitive Inhibition of Statins: http://youtu.be/Lt1-mjMFniE
(19) Acetaminophen toxicity (Clinical Correlate): [Not yet posted]
(20) Pharmacogenomics Overview: http://youtu.be/3vZxbX5P9TU
(21) Slow Acetylators - Pharmacogenomics: [not yet posted]
Help us caption & translate this video!
http://amara.org/v/B5En/
- published: 20 Sep 2012
- views: 80366
Cytochrome P450 oxidase enzyme function and co-factors/enzymes
- Order: Reorder
- Duration: 28:55
- Updated: 17 Jan 2015
- views: 2136
Video to supplement the written assignment:
References:
Guengerich, P. (2001). Chapter two, Cytochrome P450. Enzyme Systems that Metabolise Drugs and Other X...
Video to supplement the written assignment:
References:
Guengerich, P. (2001). Chapter two, Cytochrome P450. Enzyme Systems that Metabolise Drugs and Other Xenobiotics. John Wiley & Sons Ltd.
Marieb, E. (1998) Human Anatomy & Physiology 4th Edition. Benjamin Cummings. Menlo Park, California.
University of Calgary. (2015). Lecture 25, Homonuclear Diatomic Molecules II. Retrieved on January 6, 2015 from http://www.cobalt.chem.ucalgary.ca/ziegler/Lec.chm373/lec27/Lecture27.pdf
University of Florida. (2015). Module two notes. Retrieved on January 6, 2015 from https://lss.at.ufl.edu/
wn.com/Cytochrome P450 Oxidase Enzyme Function And Co Factors Enzymes
Video to supplement the written assignment:
References:
Guengerich, P. (2001). Chapter two, Cytochrome P450. Enzyme Systems that Metabolise Drugs and Other Xenobiotics. John Wiley & Sons Ltd.
Marieb, E. (1998) Human Anatomy & Physiology 4th Edition. Benjamin Cummings. Menlo Park, California.
University of Calgary. (2015). Lecture 25, Homonuclear Diatomic Molecules II. Retrieved on January 6, 2015 from http://www.cobalt.chem.ucalgary.ca/ziegler/Lec.chm373/lec27/Lecture27.pdf
University of Florida. (2015). Module two notes. Retrieved on January 6, 2015 from https://lss.at.ufl.edu/
- published: 17 Jan 2015
- views: 2136
-
Cytochrome P450 2e1: Its Role in Disease and
Weitere Informationen über Amazon-Deutschland: http://bit.ly/29ljoFQ -
Drug Metabolizing Enzymes Cytochrome P450 and Other Enzymes
Weitere Informationen über Amazon-Deutschland: http://bit.ly/28XyYVL -
Cytochrome P450 Part C 357 in Enzymology
Weitere Informationen über Amazon-Deutschland: http://bit.ly/28V3RJy -
Cytochrome P450 2d6 Structure Function Regulation and Polymorphism
Weitere Informationen über Amazon-Deutschland: http://bit.ly/28TIN43 -
Cytochrome P450, Part C, Volume 357 Methods in Enzymology
-
Concise Guide to the Cytochrome P450 System Drug Interaction Guidelines for Medical Practice
-
-
-
Cytochrome P450, Volume 206 Volume 206 Protein Dna Interactions Methods in Enzymology
-
Cytochrome P450 2e1: Its Role in Disease and
- Order: Reorder
- Duration: 1:22
- Updated: 02 Jul 2016
- views: 2
Weitere Informationen über Amazon-Deutschland: http://bit.ly/29ljoFQ
Weitere Informationen über Amazon-Deutschland: http://bit.ly/29ljoFQ
wn.com/Cytochrome P450 2E1 Its Role In Disease And
Weitere Informationen über Amazon-Deutschland: http://bit.ly/29ljoFQ
- published: 02 Jul 2016
- views: 2
Drug Metabolizing Enzymes Cytochrome P450 and Other Enzymes
- Order: Reorder
- Duration: 1:21
- Updated: 27 Jun 2016
- views: 2
Weitere Informationen über Amazon-Deutschland: http://bit.ly/28XyYVL
Weitere Informationen über Amazon-Deutschland: http://bit.ly/28XyYVL
wn.com/Drug Metabolizing Enzymes Cytochrome P450 And Other Enzymes
Weitere Informationen über Amazon-Deutschland: http://bit.ly/28XyYVL
- published: 27 Jun 2016
- views: 2
Cytochrome P450 Part C 357 in Enzymology
- Order: Reorder
- Duration: 0:53
- Updated: 25 Jun 2016
- views: 0
Weitere Informationen über Amazon-Deutschland: http://bit.ly/28V3RJy
Weitere Informationen über Amazon-Deutschland: http://bit.ly/28V3RJy
wn.com/Cytochrome P450 Part C 357 In Enzymology
Weitere Informationen über Amazon-Deutschland: http://bit.ly/28V3RJy
- published: 25 Jun 2016
- views: 0
Cytochrome P450 2d6 Structure Function Regulation and Polymorphism
- Order: Reorder
- Duration: 1:28
- Updated: 25 Jun 2016
- views: 0
Weitere Informationen über Amazon-Deutschland: http://bit.ly/28TIN43
Weitere Informationen über Amazon-Deutschland: http://bit.ly/28TIN43
wn.com/Cytochrome P450 2D6 Structure Function Regulation And Polymorphism
Weitere Informationen über Amazon-Deutschland: http://bit.ly/28TIN43
- published: 25 Jun 2016
- views: 0
Cytochrome P450, Part C, Volume 357 Methods in Enzymology
- Order: Reorder
- Duration: 1:01
- Updated: 13 Jun 2016
- views: 1
- published: 13 Jun 2016
- views: 1
Concise Guide to the Cytochrome P450 System Drug Interaction Guidelines for Medical Practice
- Order: Reorder
- Duration: 1:09
- Updated: 13 Jun 2016
- views: 4
- published: 13 Jun 2016
- views: 4
Gene Music using Protein Sequence of CYP2A7 "CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 7"
- Order: Reorder
- Duration: 1:53
- Updated: 08 Jun 2016
- views: 2
Ryan K - Cytochrome P450 (Original Mix) [Aria Knights]
- Order: Reorder
- Duration: 7:15
- Updated: 06 Jun 2016
- views: 36
Title: Cytochrome P450 (Original Mix)
Artiste : Ryan K
Label : Aria Knights Records
Genre : Trance , Uplifting Trance
Time : 07:14
Year : 2016
Title: Cytochrome P450 (Original Mix)
Artiste : Ryan K
Label : Aria Knights Records
Genre : Trance , Uplifting Trance
Time : 07:14
Year : 2016
wn.com/Ryan K Cytochrome P450 (Original Mix) Aria Knights
Cytochrome P450, Volume 206 Volume 206 Protein Dna Interactions Methods in Enzymology
- Order: Reorder
- Duration: 0:51
- Updated: 29 Apr 2016
- views: 2
- published: 29 Apr 2016
- views: 2
Cytochrome P450 Genotype Panel
- Order: Reorder
- Duration: 5:25
- Updated: 27 Apr 2016
- views: 59
ARUP Test Number: 2013098
This genotype panel can be used to detect adverse drug reactions in patients before they are ever administered a single dose.
ARUP Test Number: 2013098
This genotype panel can be used to detect adverse drug reactions in patients before they are ever administered a single dose.
wn.com/Cytochrome P450 Genotype Panel
-
What are Cytochrome P 450 Enzymes
An introduction to this this important superfamily of enzymes and their importance in drug metabolism/biotransformation. -
Enzyme Induction & Inhibition....... Explained with Animations
Natural Products also act as inhibitors of CPY microsomal system like ... Grape fruit !!! Few environmental pollutants can also induce or inhibit microsomal enzymes .. on chronic exposure. -
Gianfranco Gilardi, Structural Basis of Cytochrome P450
Il 25 giugno 2014 l'Accademia delle Scienze ha organizzato, in collaborazione col Centro Interdipartimentale di Ricerca per lo Sviluppo della Cristallografia Diffrattometrica dell'Università di Torino (CrisDi), un convegno internazionale in occasione dell'Anno internazionale della cristallografia: Impact of Crystallography on Modern Science. Il Socio Gianfranco Gilardi ha tenuto un intervento dal titolo: Structural Basis of Cytochrome P450 Function in Cell Defense and Sexual Development. -
-
Cytochrome P450 Polymorphism in West Africa
This presentation was given at the Autumn 2015 Biology Showcase at the University of Washington Bothell. Dr. Susan Kramer mentored these students. -
Quantum mechanical models of P450 metabolism to guide optimization of metabolic stability
This webinar, presented by Jon Tyzack, describes methods for prediction of metabolism of cytochrome P450 and applications to optimizing metabolic stability in the design of new compounds in pharmaceutical R&D;. -
Cytochromes P450
UEA lecture -
Cytochromes P450 II
UEA lecture -
Exploring CYP3A4 Inactivation by Lapatinib Through In Vitro Metabolite Characterization
Metabolism-dependent inhibition of cytochrome P450 enzymes has the potential to cause clinically-relevant drug-drug interactions. Alkylamine drugs are known for their propensity to cause CYP inhibition by formation of a metabolite that binds quasi-irreversibly to the ferrous heme iron of the enzyme. The secondary alkylamine drug lapatinib has been linked both to drug-induced liver injury and quasi-irreversible inhibition of CYP3A4. In the present study, in vitro techniques to probe reversibility of enzyme inactivation were combined with metabolite profiling by high-resolution liquid chromatography with accurate mass spectrometry to explore the mechanism of CYP3A4 inactivation associated with lapatinib metabolism. Key concepts discussed in this webinar will include: - Insight into metab...
What are Cytochrome P 450 Enzymes
- Order: Reorder
- Duration: 24:48
- Updated: 15 Mar 2014
- views: 7537
An introduction to this this important superfamily of enzymes and their importance in drug metabolism/biotransformation.
An introduction to this this important superfamily of enzymes and their importance in drug metabolism/biotransformation.
wn.com/What Are Cytochrome P 450 Enzymes
An introduction to this this important superfamily of enzymes and their importance in drug metabolism/biotransformation.
- published: 15 Mar 2014
- views: 7537
Enzyme Induction & Inhibition....... Explained with Animations
- Order: Reorder
- Duration: 22:24
- Updated: 31 Jul 2014
- views: 4391
Natural Products also act as inhibitors of CPY microsomal system like ... Grape fruit !!!
Few environmental pollutants can also induce or inhibit microsomal enz...
Natural Products also act as inhibitors of CPY microsomal system like ... Grape fruit !!!
Few environmental pollutants can also induce or inhibit microsomal enzymes .. on chronic exposure.
wn.com/Enzyme Induction Inhibition....... Explained With Animations
Natural Products also act as inhibitors of CPY microsomal system like ... Grape fruit !!!
Few environmental pollutants can also induce or inhibit microsomal enzymes .. on chronic exposure.
- published: 31 Jul 2014
- views: 4391
Gianfranco Gilardi, Structural Basis of Cytochrome P450
- Order: Reorder
- Duration: 37:20
- Updated: 10 Jul 2014
- views: 354
Il 25 giugno 2014 l'Accademia delle Scienze ha organizzato, in collaborazione col Centro Interdipartimentale di Ricerca per lo Sviluppo della Cristallografia Di...
Il 25 giugno 2014 l'Accademia delle Scienze ha organizzato, in collaborazione col Centro Interdipartimentale di Ricerca per lo Sviluppo della Cristallografia Diffrattometrica dell'Università di Torino (CrisDi), un convegno internazionale in occasione dell'Anno internazionale della cristallografia: Impact of Crystallography on Modern Science. Il Socio Gianfranco Gilardi ha tenuto un intervento dal titolo: Structural Basis of Cytochrome P450 Function in Cell Defense and Sexual Development.
wn.com/Gianfranco Gilardi, Structural Basis Of Cytochrome P450
Il 25 giugno 2014 l'Accademia delle Scienze ha organizzato, in collaborazione col Centro Interdipartimentale di Ricerca per lo Sviluppo della Cristallografia Diffrattometrica dell'Università di Torino (CrisDi), un convegno internazionale in occasione dell'Anno internazionale della cristallografia: Impact of Crystallography on Modern Science. Il Socio Gianfranco Gilardi ha tenuto un intervento dal titolo: Structural Basis of Cytochrome P450 Function in Cell Defense and Sexual Development.
- published: 10 Jul 2014
- views: 354
Nanophotonic detection of drug binding to cytochrome P450
- Order: Reorder
- Duration: 41:33
- Updated: 07 Jun 2012
- views: 454
Nanophotonic detection of drug binding to cytochrome P450 using localized surface plasmon resonance spectroscopy
Prof. Aditi Das, UIUC
Nanophotonic detection of drug binding to cytochrome P450 using localized surface plasmon resonance spectroscopy
Prof. Aditi Das, UIUC
wn.com/Nanophotonic Detection Of Drug Binding To Cytochrome P450
Cytochrome P450 Polymorphism in West Africa
- Order: Reorder
- Duration: 33:35
- Updated: 15 Dec 2015
- views: 47
This presentation was given at the Autumn 2015 Biology Showcase at the University of Washington Bothell. Dr. Susan Kramer mentored these students.
This presentation was given at the Autumn 2015 Biology Showcase at the University of Washington Bothell. Dr. Susan Kramer mentored these students.
wn.com/Cytochrome P450 Polymorphism In West Africa
This presentation was given at the Autumn 2015 Biology Showcase at the University of Washington Bothell. Dr. Susan Kramer mentored these students.
- published: 15 Dec 2015
- views: 47
Quantum mechanical models of P450 metabolism to guide optimization of metabolic stability
- Order: Reorder
- Duration: 48:36
- Updated: 19 Jun 2015
- views: 97
This webinar, presented by Jon Tyzack, describes methods for prediction of metabolism of cytochrome P450 and applications to optimizing metabolic stability in t...
This webinar, presented by Jon Tyzack, describes methods for prediction of metabolism of cytochrome P450 and applications to optimizing metabolic stability in the design of new compounds in pharmaceutical R&D;.
wn.com/Quantum Mechanical Models Of P450 Metabolism To Guide Optimization Of Metabolic Stability
Cytochromes P450
- Order: Reorder
- Duration: 51:11
- Updated: 24 Nov 2013
- views: 975
UEA lecture
UEA lecture
wn.com/Cytochromes P450
Cytochromes P450 II
- Order: Reorder
- Duration: 37:07
- Updated: 02 Dec 2013
- views: 160
UEA lecture
UEA lecture
wn.com/Cytochromes P450 Ii
Exploring CYP3A4 Inactivation by Lapatinib Through In Vitro Metabolite Characterization
- Order: Reorder
- Duration: 56:54
- Updated: 13 Apr 2016
- views: 40
Metabolism-dependent inhibition of cytochrome P450 enzymes has the potential to cause clinically-relevant drug-drug interactions. Alkylamine drugs are known for...
Metabolism-dependent inhibition of cytochrome P450 enzymes has the potential to cause clinically-relevant drug-drug interactions. Alkylamine drugs are known for their propensity to cause CYP inhibition by formation of a metabolite that binds quasi-irreversibly to the ferrous heme iron of the enzyme. The secondary alkylamine drug lapatinib has been linked both to drug-induced liver injury and quasi-irreversible inhibition of CYP3A4. In the present study, in vitro techniques to probe reversibility of enzyme inactivation were combined with metabolite profiling by high-resolution liquid chromatography with accurate mass spectrometry to explore the mechanism of CYP3A4 inactivation associated with lapatinib metabolism.
Key concepts discussed in this webinar will include:
- Insight into metabolism-dependent CYP inhibition by alkylamines
- Utility of in vitro reversibility assays
- Mechanism of CYP3A4 inactivation by the tyrosine kinase inhibitor lapatinib
Download slides: https://www.xenotech.com/scientific-resources/webinar-series/2013/Lapatinib-3A4-Inactivation.aspx
Questions: https://www.xenotech.com/contact-us
wn.com/Exploring Cyp3A4 Inactivation By Lapatinib Through In Vitro Metabolite Characterization
Metabolism-dependent inhibition of cytochrome P450 enzymes has the potential to cause clinically-relevant drug-drug interactions. Alkylamine drugs are known for their propensity to cause CYP inhibition by formation of a metabolite that binds quasi-irreversibly to the ferrous heme iron of the enzyme. The secondary alkylamine drug lapatinib has been linked both to drug-induced liver injury and quasi-irreversible inhibition of CYP3A4. In the present study, in vitro techniques to probe reversibility of enzyme inactivation were combined with metabolite profiling by high-resolution liquid chromatography with accurate mass spectrometry to explore the mechanism of CYP3A4 inactivation associated with lapatinib metabolism.
Key concepts discussed in this webinar will include:
- Insight into metabolism-dependent CYP inhibition by alkylamines
- Utility of in vitro reversibility assays
- Mechanism of CYP3A4 inactivation by the tyrosine kinase inhibitor lapatinib
Download slides: https://www.xenotech.com/scientific-resources/webinar-series/2013/Lapatinib-3A4-Inactivation.aspx
Questions: https://www.xenotech.com/contact-us
- published: 13 Apr 2016
- views: 40
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5:20
Pharmacokinetics 4 - Metabolism
http://www.handwrittentutorials.com - This tutorial is the fourth in the Pharmacokinetics ...
published: 14 Dec 2012
Pharmacokinetics 4 - Metabolism
Pharmacokinetics 4 - Metabolism
- Report rights infringement
- published: 14 Dec 2012
- views: 132431
1:43
Cytochrome p450 inhibitors and inducers
1.IN DEPTH ANALYSIS OF aiims, aipgmee, aipg,fmgeQUESTION PAPERS.
2.SUBJECT WISE AND TOPIC ...
published: 25 Nov 2015
Cytochrome p450 inhibitors and inducers
Cytochrome p450 inhibitors and inducers
- Report rights infringement
- published: 25 Nov 2015
- views: 3020
2:31
Cytochrome p450 Inducers and Inhibitors
http://usmlefasttrack.com/?p=5058 modafinil, barbiturates, st johns wort, phenytoin, rifa...
published: 23 Oct 2013
Cytochrome p450 Inducers and Inhibitors
Cytochrome p450 Inducers and Inhibitors
- Report rights infringement
- published: 23 Oct 2013
- views: 14058
2:17
Cytochrome P450: Radicals in a Biochemical Setting
Cytochrome P450 enzymes catalyze the oxidation of organic compounds through radical interm...
published: 29 Dec 2010
Cytochrome P450: Radicals in a Biochemical Setting
Cytochrome P450: Radicals in a Biochemical Setting
- Report rights infringement
- published: 29 Dec 2010
- views: 24480
15:32
Cytochrome P450 1
published: 20 Aug 2014
Cytochrome P450 1
Cytochrome P450 1
- Report rights infringement
- published: 20 Aug 2014
- views: 9023
18:33
Cytochrome P450 Catalytic Cycle
published: 20 Aug 2014
Cytochrome P450 Catalytic Cycle
Cytochrome P450 Catalytic Cycle
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- published: 20 Aug 2014
- views: 6659
1:13
Cytochrome P450 - Tales from the Genome
This video is part of an online course, Tales from the Genome. Check out the course here: ...
published: 23 Feb 2015
Cytochrome P450 - Tales from the Genome
Cytochrome P450 - Tales from the Genome
- Report rights infringement
- published: 23 Feb 2015
- views: 769
18:14
Biochemistry of cytochrome P 450 enzymes
Looking at the biochemistry of how cytochrome p 450 enzymes work.
published: 20 Mar 2014
Biochemistry of cytochrome P 450 enzymes
Biochemistry of cytochrome P 450 enzymes
- Report rights infringement
- published: 20 Mar 2014
- views: 6178
6:56
Phase I Metabolism - Pharmacology Lect 7
Drug Metabolism - Phase 1
A video overview of Phase I metabolism & cytochrome P450 system...
published: 20 Sep 2012
Phase I Metabolism - Pharmacology Lect 7
Phase I Metabolism - Pharmacology Lect 7
- Report rights infringement
- published: 20 Sep 2012
- views: 80366
28:55
Cytochrome P450 oxidase enzyme function and co-factors/enzymes
Video to supplement the written assignment:
References:
Guengerich, P. (2001). Chapter ...
published: 17 Jan 2015
Cytochrome P450 oxidase enzyme function and co-factors/enzymes
Cytochrome P450 oxidase enzyme function and co-factors/enzymes
- Report rights infringement
- published: 17 Jan 2015
- views: 2136
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1:22
Cytochrome P450 2e1: Its Role in Disease and
Weitere Informationen über Amazon-Deutschland: http://bit.ly/29ljoFQ
published: 02 Jul 2016
Cytochrome P450 2e1: Its Role in Disease and
Cytochrome P450 2e1: Its Role in Disease and
- Report rights infringement
- published: 02 Jul 2016
- views: 2
1:21
Drug Metabolizing Enzymes Cytochrome P450 and Other Enzymes
Weitere Informationen über Amazon-Deutschland: http://bit.ly/28XyYVL
published: 27 Jun 2016
Drug Metabolizing Enzymes Cytochrome P450 and Other Enzymes
Drug Metabolizing Enzymes Cytochrome P450 and Other Enzymes
- Report rights infringement
- published: 27 Jun 2016
- views: 2
0:53
Cytochrome P450 Part C 357 in Enzymology
Weitere Informationen über Amazon-Deutschland: http://bit.ly/28V3RJy
published: 25 Jun 2016
Cytochrome P450 Part C 357 in Enzymology
Cytochrome P450 Part C 357 in Enzymology
- Report rights infringement
- published: 25 Jun 2016
- views: 0
1:28
Cytochrome P450 2d6 Structure Function Regulation and Polymorphism
Weitere Informationen über Amazon-Deutschland: http://bit.ly/28TIN43
published: 25 Jun 2016
Cytochrome P450 2d6 Structure Function Regulation and Polymorphism
Cytochrome P450 2d6 Structure Function Regulation and Polymorphism
- Report rights infringement
- published: 25 Jun 2016
- views: 0
1:01
Cytochrome P450, Part C, Volume 357 Methods in Enzymology
published: 13 Jun 2016
Cytochrome P450, Part C, Volume 357 Methods in Enzymology
Cytochrome P450, Part C, Volume 357 Methods in Enzymology
- Report rights infringement
- published: 13 Jun 2016
- views: 1
1:09
Concise Guide to the Cytochrome P450 System Drug Interaction Guidelines for Medical Practice
published: 13 Jun 2016
Concise Guide to the Cytochrome P450 System Drug Interaction Guidelines for Medical Practice
Concise Guide to the Cytochrome P450 System Drug Interaction Guidelines for Medical Practice
- Report rights infringement
- published: 13 Jun 2016
- views: 4
1:53
Gene Music using Protein Sequence of CYP2A7 "CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 7"
Gene Music using Protein Sequence of CYP2A7 "CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYP...
published: 08 Jun 2016
Gene Music using Protein Sequence of CYP2A7 "CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 7"
7:15
Ryan K - Cytochrome P450 (Original Mix) [Aria Knights]
Title: Cytochrome P450 (Original Mix)
Artiste : Ryan K
Label : Aria Knights Records
Genre ...
published: 06 Jun 2016
Ryan K - Cytochrome P450 (Original Mix) [Aria Knights]
Ryan K - Cytochrome P450 (Original Mix) [Aria Knights]
- Report rights infringement
- published: 06 Jun 2016
- views: 36
0:51
Cytochrome P450, Volume 206 Volume 206 Protein Dna Interactions Methods in Enzymology
published: 29 Apr 2016
Cytochrome P450, Volume 206 Volume 206 Protein Dna Interactions Methods in Enzymology
Cytochrome P450, Volume 206 Volume 206 Protein Dna Interactions Methods in Enzymology
- Report rights infringement
- published: 29 Apr 2016
- views: 2
5:25
Cytochrome P450 Genotype Panel
ARUP Test Number: 2013098
This genotype panel can be used to detect adverse drug reactio...
published: 27 Apr 2016
Cytochrome P450 Genotype Panel
Cytochrome P450 Genotype Panel
- Report rights infringement
- published: 27 Apr 2016
- views: 59
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24:48
What are Cytochrome P 450 Enzymes
An introduction to this this important superfamily of enzymes and their importance in drug...
published: 15 Mar 2014
What are Cytochrome P 450 Enzymes
What are Cytochrome P 450 Enzymes
- Report rights infringement
- published: 15 Mar 2014
- views: 7537
22:24
Enzyme Induction & Inhibition....... Explained with Animations
Natural Products also act as inhibitors of CPY microsomal system like ... Grape fruit !!!
...
published: 31 Jul 2014
Enzyme Induction & Inhibition....... Explained with Animations
Enzyme Induction & Inhibition....... Explained with Animations
- Report rights infringement
- published: 31 Jul 2014
- views: 4391
37:20
Gianfranco Gilardi, Structural Basis of Cytochrome P450
Il 25 giugno 2014 l'Accademia delle Scienze ha organizzato, in collaborazione col Centro I...
published: 10 Jul 2014
Gianfranco Gilardi, Structural Basis of Cytochrome P450
Gianfranco Gilardi, Structural Basis of Cytochrome P450
- Report rights infringement
- published: 10 Jul 2014
- views: 354
41:33
Nanophotonic detection of drug binding to cytochrome P450
Nanophotonic detection of drug binding to cytochrome P450 using localized surface plasmon ...
published: 07 Jun 2012
Nanophotonic detection of drug binding to cytochrome P450
Nanophotonic detection of drug binding to cytochrome P450
- Report rights infringement
- published: 07 Jun 2012
- views: 454
33:35
Cytochrome P450 Polymorphism in West Africa
This presentation was given at the Autumn 2015 Biology Showcase at the University of Washi...
published: 15 Dec 2015
Cytochrome P450 Polymorphism in West Africa
Cytochrome P450 Polymorphism in West Africa
- Report rights infringement
- published: 15 Dec 2015
- views: 47
48:36
Quantum mechanical models of P450 metabolism to guide optimization of metabolic stability
This webinar, presented by Jon Tyzack, describes methods for prediction of metabolism of c...
published: 19 Jun 2015
Quantum mechanical models of P450 metabolism to guide optimization of metabolic stability
Quantum mechanical models of P450 metabolism to guide optimization of metabolic stability
- Report rights infringement
- published: 19 Jun 2015
- views: 97
37:07
Cytochromes P450 II
UEA lecture
published: 02 Dec 2013
Cytochromes P450 II
56:54
Exploring CYP3A4 Inactivation by Lapatinib Through In Vitro Metabolite Characterization
Metabolism-dependent inhibition of cytochrome P450 enzymes has the potential to cause clin...
published: 13 Apr 2016
Exploring CYP3A4 Inactivation by Lapatinib Through In Vitro Metabolite Characterization
Exploring CYP3A4 Inactivation by Lapatinib Through In Vitro Metabolite Characterization
- Report rights infringement
- published: 13 Apr 2016
- views: 40
What are Cytochrome P 450 Enzymes...
Enzyme Induction & Inhibition....... Explained wit...
Gianfranco Gilardi, Structural Basis of Cytochrome...
Nanophotonic detection of drug binding to cytochro...
Cytochrome P450 Polymorphism in West Africa...
Quantum mechanical models of P450 metabolism to gu...
Cytochromes P450...
Cytochromes P450 II...
Exploring CYP3A4 Inactivation by Lapatinib Through...
photo: Wikileaks
WikiLeaks Releases Stolen Audio From Top Democrats' Leaked Emails
Edit Voa News 28 Jul 2016
WikiLeaks released 29 audio recordings Wednesday that it said were taken from Democratic National Committee servers. The voicemails, apparently copied from email accounts of seven DNC members, included party associates upset by Bernie Sanders influence on the Democratic Party....
photo: AP / Tony Dejak
Nina Turner, Prominent Sanders Delegate, Ejected from DNC
Edit Common Dreams 27 Jul 2016
Jon Queally, staff writer. Developing... Check back for updates... Just before former president Bill Clinton took the stage at the Democratic National Convention on Tuesday night, progressive social media lit up with news that former Ohio state senator Nina Turner, one of Bernie Sanders' most celebrated surrogates, had her convention credentials stripped by the DNC and was ejected from the convention hall. On Twitter. ... ....
photo: Public Domain / Official Navy Page
Panetta: Trump Email Statements Question If He's Conspiring With Foreign Power
Edit WorldNews.com 27 Jul 2016
into question.What’s more, Amanpour says Panetta claims Trump’s statements raise questions if he’s conspiring with a foreign power, the report said. “You have a presidential candidate who is, in fact, asking the Russians to engage in American politics ... He is scheduled to be one of the keynote speakers during tonight’s Democratic National Convention.– WN.com, Jack Durschlag....
photo: Creative Commons / Chmee2
More Colorado Children Hospitalized For Marijuana Since Legalization, Study Says
Edit WorldNews.com 28 Jul 2016
32 visits for the first two years after legalization, against 30 visits for the four years prior, according to the study.Nearly half of the hospital visits since 2009 involved edibles such as brownies and candies. And almost half of the hospital cases in 2014 and 2015 involved recreational, as opposed to medical, marijuana, said the study led by Dr ... – Dr ... The study's authors say more thought needs to be put into prevention....
photo: AP / Jacques Brinon
FBI warns of increased Islamic violence in Europe
Edit The Irish Times 28 Jul 2016
US intelligence has warned that Europe faces a new wave of Islamist violence on an even greater scale, concentrated on Paris and Brussels. “At some point there’s going to be a terrorist diaspora out of Syria like we’ve never seen before,” said James Comey, director of the Federal Bureau of Investigations in New York ... The recent terrorist attacks in Europe have increased pressure for a crackdown from the continent’s governments ... Unity ... ....
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What Is Cassava Good For?
Edit Mercola 25 Jul 2016
You might be wondering what cassava is before you think to ask what it might be good for, but in light of its amazing properties, this rather sweet, starchy and nut-flavored tuber may become a staple in your pantry ... For centuries, it's been a food mainstay for millions ... sweet cassava and bitter cassava ... Cassava ... Cyanide compounds interfere with cellular metabolism by inhibiting the cytochrome-oxidase enzyme inside the human body."20 ... ....
P450 redox partner interactions [Biophysics and Computational Biology]>
Edit PNAS 21 Jul 2016
The heme iron of cytochromes P450 must be reduced to bind and activate molecular oxygen for substrate oxidation. Reducing equivalents are derived from a redox partner, which requires the formation of a protein–protein complex. A subject of increasing discussion is the role that redox partner binding plays, if any, in... ....
Bovine cytochrome c oxidase is dimeric [Biophysics and Computational Biology]>
Edit PNAS 20 Jul 2016
Bovine cytochrome c oxidase is an integral membrane protein complex comprising 13 protein subunits and associated lipids. Dimerization of the complex has been proposed; however, definitive evidence for the dimer is lacking. We used advanced mass spectrometry methods to investigate the oligomeric state of cytochrome c oxidase and the potential... ....
Regulation of respiration in S. cerevisiae [Biochemistry]>
Edit PNAS 19 Jul 2016
The respiratory supercomplex factors (Rcf) 1 and 2 mediate supramolecular interactions between mitochondrial complexes III (ubiquinol-cytochrome c reductase; cyt. bc1) and IV (cytochrome c oxidase; CytcO). In addition, removal of these polypeptides results in decreased activity of CytcO, but not of cyt. bc1. In the present study, we have investigated... ....
Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (American College of Cardiology Foundation)
Edit Public Technologies 19 Jul 2016
... Need for chronic non-steroidal anti-inflammatory drug Use of a cytochrome P450 inhibitor Pregnancy or breast-feeding Contraindication to warfarin Known HIV infection Creatinine clearance Significant liver disease Limited life expectancy Drug or alcohol addiction Receipt of another experimental drug Allergy to any component of the study medication....
International team describes step-by-step progress in battling toxoplasmosis (The University of Chicago Medical Center)
Edit Public Technologies 18 Jul 2016
(Source. The University of Chicago Medical Center). July 18, 2016 ... Especially appealing was the parasite's mitochondrial protein, cytochrome b. The team was able to develop compounds more soluble than existing cytochrome b inhibiting quinolones ... This work emphasizes that the cytochrome bc 1 complex 'is a critical target.' Co-crystallography of the enzyme with the inhibitor provides information to optimize inhibitory compounds ... ### ... 950 E....
ASPET DMD Journal announcement: Special Section on Emerging Novel Enzyme Pathways in Drug Metabolism (FASEB - Federation of American Societies for Experimental Biology)
Edit Public Technologies 13 Jul 2016
Dalvie (Pfizer), highlights a number of recent advancements that have been reported surrounding novel biotransformation pathways, particularly those of a non-cytochrome P450 nature ... of xenobiotic compounds has taken on increased importance given the ability of the field to systematically 'design-out' cytochrome P450-catalyzed metabolic pathways....
Detecting melanoma early, without a biopsy (Colorado State University)
Edit Public Technologies 13 Jul 2016
(Source. Colorado State University). Melanoma is a form of skin cancer that becomes dangerous when it spreads, but is treatable in its early stages ... Credit. Jesse Wilson/Duke University, published in Journal of Biomedical Optics, 2014 ... Cost is a barrier ... Wilson's lab is also pursuing other pump-probe applications, including imaging cytochromes, molecules involved in metabolic activities that can't be imaged with conventional techniques....
Evaluating electrogenicity of cytochrome c oxidase [Biophysics and Computational Biology]>
Edit PNAS 12 Jul 2016
Measurements of voltage changes in response to charge separation within membrane proteins can offer fundamental information on spectroscopically “invisible” steps. For example, results from studies of voltage changes associated with electron and proton transfer in cytochrome c oxidase could, in principle, be used to discriminate between different theoretical models describing... ....
Organovo and Roche Researchers Publish Data Demonstrating Superiority of 3D Bioprinted Human Liver Tissues in Assessing Drug-Induced Toxicity (Organovo Holdings Inc)
Edit Public Technologies 11 Jul 2016
(Source. Organovo Holdings Inc). SAN DIEGO, July 11, 2016 (GLOBE NEWSWIRE) -- Organovo Holdings, Inc ... The hepatotoxic potential of trovafloxacin was not originally identified by traditional preclinical tests including animal studies ... Deborah G ... Unlike 2D cell cultures, Organovo's tissues maintained metabolically relevant levels of ATP and albumin and drug-induced enzyme activity of cytochrome P450s for more than four weeks in culture. Dr....
The CBD User's Manual: Everything You Need to Know About Marijuana's Most Medicinal Molecule
Edit Alternet 09 Jul 2016
And we have a primer on it just for you ... CBD or THC? ... At sufficient dosages, CBD will temporarily deactivate cytochrome P450 enzymes, thereby altering how we metabolize a wide range of compounds, including THC. Cytochrome> P450 enzymes metabolize more than 60 percent of Big Pharma meds. CBD is a more potent inhibitor of cytochrome P450 than the grapefruit compound Bergapten, so ask your doctor if grapefruit interacts with your medication....
European Commission Grants Marketing Authorization for Gilead’s Epclusa® (Sofosbuvir/Velpatasvir) for the Treatment of All Genotypes ...
Edit Stockhouse 08 Jul 2016
European Commission Grants Marketing Authorization for Gilead’s Epclusa® (Sofosbuvir/Velpatasvir) for the Treatment of All Genotypes of Chronic Hepatitis C. – Epclusa is the First and Only All-Oral, Single Tablet Regimen for all Genotypes (1-6) of Chronic Hepatitis C Virus Infection and is Gilead’s Third Sofosbuvir-Based Treatment – ... Co-administration with potent P-glycoprotein (P-gp) or potent cytochrome P450 (CYP) inducers (e.g....
European Commission Grants Marketing Authorization for Gilead’s Epclusa® (Sofosbuvir/Velpatasvir) for the Treatment of All Genotypes of Chronic Hepatitis C (Gilead Sciences Inc)
Edit Public Technologies 08 Jul 2016
(Source. Gilead Sciences Inc). - Epclusa is the First and Only All-Oral, Single Tablet Regimen for all Genotypes (1-6) of Chronic Hepatitis C Virus Infection and is Gilead's Third Sofosbuvir-Based Treatment -. FOSTER CITY, Calif.--(BUSINESS WIRE)--Jul. 8, 2016-- Gilead Sciences, Inc ... Epclusa was approved by the U.S ... Co-administration with potent P-glycoprotein (P-gp) or potent cytochrome P450 (CYP) inducers (e.g. rifampicin, rifabutin, St....
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