Latest News for: reticulum

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Endoplasmic reticulum membrane receptors of the GET pathway are conserved throughout eukaryotes [Plant Biology]

PNAS 21 Dec 2020
... endoplasmic reticulum (ER) via the Guided-Entry of TA proteins (GET) pathway.
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Selenoprotein N is an endoplasmic reticulum calcium sensor that links luminal calcium levels to a ...

PNAS 01 Sep 2020
The endoplasmic reticulum (ER) is the reservoir for calcium in cells ... .
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Protein Atg40 folds the endoplasmic reticulum to facilitate its autophagy, study finds

PhysOrg 23 Jul 2020
The endoplasmic reticulum (ER) is an important part of eukaryotic cells (the type of cells that make up every living thing other than bacteria ...
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Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1 [Biophysics and Computational Biology]

PNAS 26 Dec 2019
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an intracellular enzyme ...
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Bull swallows gold mangalsutra worth Rs 1.5 lakh. Vet extracts it from reticulum

Indiatoday 13 Sep 2019
Bull swallows Rs 1.5 lakh gold mangalsutra. Vet pulls it from reticulum ... .
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Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis [Genetics]

PNAS 27 Aug 2019
Unfolded protein response (UPR) of the endoplasmic reticulum (UPRER) helps maintain proteostasis in the cell. The ability to mount an effective UPRER to external stress (iUPRER) decreases with age and is linked to the pathophysiology of multiple age-related disorders. Here, we show that a transient pharmacological ER stress, imposed early... .
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Restoration of Proteostasis in the Endoplasmic Reticulum Reverses an Inflammation-Like Response to Cytoplasmic DNA in ...

Genetics 12 Aug 2019
Innate immune responses protect organisms against various insults, but may lead to tissue damage when aberrantly activated ... Our results establish C ... .
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Atlastin-mediated membrane tethering is critical for cargo mobility and exit from the endoplasmic reticulum [Cell Biology]

PNAS 09 Jul 2019
Endoplasmic reticulum (ER) membrane junctions are formed by the dynamin-like GTPase atlastin (ATL). Deletion of ATL results in long unbranched ER tubules in cells, and mutation of human ATL1 is linked to hereditary spastic paraplegia. Here, we demonstrate that COPII formation is drastically decreased in the periphery of ATL-deleted cells.... .
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Discovery of endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome [Medical Sciences]

PNAS 09 Jul 2019
Emerging evidence has established primary nephrotic syndrome (NS), including focal segmental glomerulosclerosis (FSGS), as a primary podocytopathy. Despite the underlying importance of podocyte endoplasmic reticulum (ER) stress in the pathogenesis of NS, no treatment currently targets the podocyte ER ... .
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