Documentary on Small Pox
Smallpox was an infectious disease caused by either of two virus variants,
Variola major and
Variola minor.[1] The disease is also known by the
Latin names Variola or
Variola vera, derived from varius ("spotted") or varus ("pimple"). The disease was originally known in
English as the "pox" or "red plague"; the term "smallpox" was first used in
Britain in the
15th century to distinguish variola from the "great pox" (syphilis). The last naturally occurring case of smallpox (Variola minor) was diagnosed on
26 October 1977.
Smallpox was localized in small blood vessels of the skin and in the mouth and throat
. In the skin it resulted in a characteristic maculopapular rash and, later, raised fluid-filled blisters. V. major produced a more serious disease and had an overall mortality rate of 30–35%. V. minor caused a milder form of disease (also known as alastrim, cottonpox, milkpox, whitepox, and Cuban itch) which killed about 1% of its victims. Long-term complications of V. major infection included characteristic scars, commonly on the face, which occur in 65–85% of survivors.
Blindness resulting from corneal ulceration and scarring, and limb deformities due to arthritis and osteomyelitis were less common complications, seen in about 2–5% of cases.
Smallpox is believed to have emerged in human populations about
10,000 BC. The earliest physical evidence of it is probably the pustular rash on the mummified body of
Pharaoh Ramses V of
Egypt.[9] The disease killed an estimated 400,
000 Europeans annually during the closing years of the
18th century (including five reigning monarchs), and was responsible for a third of all blindness. Of all those infected, 20–60%—and over 80% of infected children—died from the disease. Smallpox was responsible for an estimated
300–
500 million deaths during the
20th century. As recently as 1967, the
World Health Organization (WHO) estimated that 15 million people contracted the disease and that two million died in that year.
After vaccination campaigns throughout the 19th and
20th centuries, the WHO certified the eradication of smallpox in
1979. Smallpox is one of two infectious diseases to have been eradicated, the other being rinderpest, which was declared eradicated in
2011.
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- published: 20 Dec 2014
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