Pope Pius VIII (20 November 1761 – 30 November 1830), born Francesco Saverio Castiglioni was Pope in 1829 and 1830.

He was born in Cingoli, Marche, the son of Count Ottavio Castiglioni and his wife Sanzia Ghislieri. He studied Canon law and, in 1800 became bishop of Montalto. After he refused to swear allegiance to Napoleon I of France (1804–14, 1815) he was taken to France, but following the defeat of France, he was, in 1816, made a Cardinal-Priest of Santa Maria in Traspontina. He held various high offices thereafter, including that of Major Penitentiary. He soon became cardinal bishop of the suburbicarian see of Frascati.

"As a Cardinal, Castiglione had continued to live modestly, made no enemies, and although his own private life had always been irreproachable, he had shown no signs of censoriousness where others were concerned. He suffered from a very painful and distressing complaint, having perpetually suppurating sores on his neck and body, and was far too ill and feeble to do more than sign the documents presented to him by Cardinal Giuseppe Albani, who ruled the Papal States as autocratically as though he had himself worn the triple crown."

Blessed Pope Pius IX (13 May 1792 – 7 February 1878), born Giovanni Maria Mastai-Ferretti, was the longest-reigning elected Pope in the history of the Catholic Church, serving from 16 June 1846 until his death, a period of nearly 32 years. During his pontificate, he convened the First Vatican Council in 1869, which decreed papal infallibility. The Pope defined the dogma of the Immaculate Conception of the Blessed Virgin Mary, meaning that Mary was conceived without original sin. Pius IX also granted the Marian title of Our Mother of Perpetual Help, a famous Byzantine icon from Crete entrusted to the Redemptorist priests. In addition to this, Pius IX was also the last Pope to rule as the Sovereign of the Papal States, which fell completely to Italian nationalist armies by 1870 and were incorporated into the Kingdom of Italy. He was beatified in 2000.

Pope Pius VI (25 December 1717 – 29 August 1799), born Count Giovanni Angelo Braschi, was Pope from 1775 to 1799.

Braschi was born in Cesena. After completing his studies in the Jesuit college of Cesena and receiving his doctorate of law (1734), Braschi continued his studies at the University of Ferrara, where he became the private secretary of Tommaso Ruffo, papal legate, in whose bishopric of Ostia and Velletri he held the post of auditor until 1753. His skill in the conduct of a mission to the court of Naples won him the esteem of Pope Benedict XIV (1740–58), who appointed him one of his secretaries, 1753, and canon of St Peter's. In 1758, putting an end to an engagement to be married (Pastor 1952) he was ordained priest, and in 1766 appointed treasurer of the camera apostolica by Pope Clement XIII (1758–69). Those who suffered under his conscientious economies cunningly convinced Pope Clement XIV (1769–74) to make him Cardinal-Priest of Sant'Onofrio on 26 April 1773 – a promotion which rendered him, for a time, innocuous. In the four months' conclave which followed the death of Clement XIV Spain, France and Portugal at length dropped their objection to Braschi, who was after all one of the more moderate opponents of the anti-Jesuit policy of the previous Pope, and he was elected to the Holy See on 15 February 1775, taking the name of Pius VI.

Pope Alexander VI (Spanish: Alejandro VI, or Alexander Sextus), born Roderic Llançol i de Borja (Spanish: Rodrigo Lanzol; 1 January 1431 – 18 August 1503) was pope (Bishop of Rome) from 1492 until his death in 1503. He is one of the most controversial of the Renaissance popes, and his Italianized surname Borgia became a byword for libertinism and nepotism, which are traditionally considered as characterizing his papacy. However, his reputation is mostly drawn from his enemies, the Italian prelates and barons whose power he subverted. Two of Alexander's successors, Sixtus V and Urban VIII, described him as one of the most outstanding popes since St. Peter. His reputation rests more on his considerable skills as a diplomat, politician and civil administrator rather than as a pastor, although regarding the latter he was no more or less effective than any of the other renaissance pontiffs.

Rodrigo Llançol was born on 1 January 1431 in the town of Xàtiva in the Kingdom of Valencia, one of the component realms of the Crown of Aragon, in present-day Spain. His parents were the Valencian Jofré Llançol i Escrivà (died bef. 24 March 1437) and his wife and distant cousin the Aragonese Isabel de Borja y Cavanilles (died 19 October 1468). His family name is written Llançol in Valencian and Lanzol in Spanish. Rodrigo adopted his mother's family name of Borja in 1455 following the elevation to the papacy of his maternal uncle Alonso de Borja (Italianized to Alfonso Borgia) as Calixtus III.

Pope Pius II, born Enea Silvio Piccolomini (Latin Aeneas Sylvius; 18 October 1405 – 14 August 1464) was Pope from 19 August 1458 until his death in 1464. Pius II was born at Corsignano in the Sienese territory of a noble but decayed family. His longest and most enduring work is the story of his life, the Commentaries, which is the only autobiography ever written by a reigning Pope.

After studying at the universities of Siena and Florence, he settled in the former city as a teacher, but in 1431 accepted the post of secretary to Domenico Capranica, bishop of Fermo, then on his way to the Council of Basel (1431–39). Capranica was protesting against the new Pope Eugene IV's refusal of a cardinalate for him, which had been designated by Pope Martin V. Arriving at Basel after enduring a stormy voyage to Genoa and then a trip across the Alps, he successively served Capranica, who ran short of money, and then other masters.

In 1435 he was sent by Cardinal Albergati, Eugenius IV's legate at the council, on a secret mission to Scotland, the object of which is variously related even by himself. He visited England as well as Scotland, underwent many perils and vicissitudes in both countries, and left a valuable account of each. The journey to Scotland proved so tempestuous that Piccolomini swore that he would walk barefoot to the nearest shrine of Our Lady from their landing port. This proved to be Dunbar; the nearest shrine was 10 miles distant at Whitekirk. The journey through the ice and snow left Aeneas afflicted with pain in his legs for the rest of his life. In Scotland he fathered his second natural child, the other one having been born in Strasbourg.