The Nitra Region (Slovak: Nitriansky kraj; Hungarian: Nyitrai kerület) is one of the administrative regions of Slovakia.
This region with a long history is situated in the southwest of Slovakia, mostly in the eastern part of the Danubian Lowland. It is divided into two sub-units: the Danubian Flat in the south-west, with eastern part of the Žitný ostrov island, and the Danubian Hills in the north, centre and east. Mountain ranges reaching into the region are: Považský Inovec in the north-west, where the region's highest point, Veľký Inovec, is located, Tribeč in the north from Nitra, Pohronský Inovec in the north-east and Štiavnické vrchy in the east. Major rivers are the Danube in the south, Váh in the south-west, Nitra in the western-central part, Hron in the east and Ipeľ in the south-east. As for administrative divisions, the region borders Trenčín Region in the north, Banská Bystrica Region in the east, Hungarian Pest in the south-east, Komárom-Esztergom in the south, and Győr-Moson-Sopron county in the south-west and Trnava Region in the west.