John Charles Frémont or Fremont (January 21, 1813 – July 13, 1890) was an American military officer, explorer, and politician who became the first candidate of the anti-slavery Republican Party for the office of President of the United States. During the 1840s, when he led four expeditions into the American West, that era's penny press and admiring historians accorded Frémont the sobriquet The Pathfinder.
During the Mexican–American War, Frémont, a major in the U.S. Army, took control of California from the Bear Flag Republic in 1846. Frémont then proclaimed himself military Governor of California; however, for that he was convicted in court martial for mutiny and insubordination. After President Polk commuted his sentence, Frémont led a fourth expedition, which cost ten lives, seeking a rail route over the mountains around the 38th parallel in the winter of 1849. He retired from military service and settled in California. Frémont acquired massive wealth during the California Gold Rush, but he was soon bogged down with lawsuits over land claims, between the dispossession of various land owners during the Mexican–American War and the explosion of Forty-Niners immigrating during the California Gold Rush. These cases were settled by the U.S. Supreme Court allowing Frémont to keep his property. Frémont became one of the first two U.S. senators elected from the new state of California in 1850. He was the first presidential candidate of the new Republican Party, carrying most of the North. He lost the 1856 presidential election to Democrat James Buchanan when Know-Nothings split the vote and Democrats warned his election would lead to civil war.
Boldklubben Frem (also known as Frem, BK Frem or BK Frem Copenhagen) is a Danish sports club based in the Valby-Sydhavnen area of Copenhagen. It is best known for its semi-professional football team. Since its foundation in 1886, Frem has won the Danish Championships six times and the Danish Cup twice. Until the disastrous bankruptcy in 1993, Frem had played in the top division all but six seasons. After the bankruptcy the club fought its way back to the top of Danish football, but in 2010 it went bankrupt again and was demoted to the Copenhagen Series – the fifth tier in the Danish league system. After two back to back promotions, the club now participates in the Danish 2. Division, the third tier.
The club also has a youth and amateur football branch, as well as a cricket team. It is also involved in the running of the KIES sports boarding school.
Frem's official supportergroup is called "BK Frem Support". It is Denmarks oldest supporters club, formed in 1986. Frem fans are especially known for being very loyal. Even when demoted to the fifth tier, attendances almost didn't drop.
FRAS1-related extracellular matrix protein 2 is a protein that in humans is encoded by the FREM2 gene.
This gene encodes a membrane protein that belongs to the FRAS1 family. This extracellular matrix protein is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes. Mutations in this gene are associated with Fraser syndrome.