Houston ( /ˈhjuːstən/) (Alibamu: Yosti ) is the largest city in the state of Texas, and the fourth-largest city in the United States. According to the 2010 U.S. Census, the city had a population of 2.1 million people within an area of 656.3 square miles (1,700 km²). Houston is the seat of Harris County and the economic center of Houston–Sugar Land–Baytown, which is the fifth-largest metropolitan area in the United States, with 6.08 million people as of July 1st, 2011.

Houston was founded in 1836 on land near the banks of Buffalo Bayou. It was incorporated as a city on June 5, 1837, and named after then-President of the Republic of Texas—former General Sam Houston—who had commanded at the Battle of San Jacinto, which took place 25 miles (40 km) east of where the city was established. The burgeoning port and railroad industry, combined with oil discovery in 1901, has induced continual surges in the city's population. In the mid-twentieth century, Houston became the home of the Texas Medical Center—the world's largest concentration of healthcare and research institutions—and NASA's Johnson Space Center, where the Mission Control Center is located.

The University of Houston is a state research university, and is the flagship institution of the University of Houston System. Founded in 1927, it is Texas's third-largest university with nearly 40,000 students. Its campus spans 667 acres in southeast Houston, and was known as University of Houston–University Park from 1983 to 1991. The Carnegie Foundation classifies UH as a top-tier research university. The institution ranks in the Top 50 American Research Universities, and is among the Top 300 Academic Ranking of World Universities.

The university offers over 300 degree programs through its 12 academic colleges on campus—including programs leading to professional degrees in law, optometry, and pharmacy. The institution conducts nearly $130 million annually in research, and operates more than 40 research centers and institutes on campus. Interdisciplinary research includes superconductivity, space commercialization and exploration, biomedical sciences and engineering, energy and natural resources, and artificial intelligence. Awarding more than 7,800 degrees annually, UH's alumni base exceeds 260,000. The economic impact of the university contributes over $3 billion annually to the Texas economy, while generating about 24,000 jobs.