- published: 19 May 2016
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Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM.
The gene for TFPI is located on chromosome 2q31-q32.1, and has nine exons which span 70 kb. The gene has not been completely sequenced yet. A similar gene, termed TFPI2, has been identified on chromosome 7q22; in addition to TFPI activity, its product also has retinal pigment epithelial cell growth-promoting properties.
TFPI has a relative molecular mass of 34,000 to 40,000 depending on the degree of proteolysis of the C-terminal region.
TFPI consists of a highly negatively-charged amino-terminus, three tandemly-linked Kunitz domains, and a highly positively-charged carboxy-terminus. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypsin inhibitor and bovine basic pancreatic trypsin inhibitor.
Green is a color, the perception of which is evoked by light having a spectrum dominated by energy with a wavelength of roughly 520–570 nanometers. In the subtractive color system, it is not a primary color, but is created out of a mixture of yellow and blue, or yellow and cyan; it is considered one of the additive primary colors. On the HSV color wheel, also known as the RGB color wheel, the complement of green is magenta; that is, a purple color corresponding to an equal mixture of red and blue light. On a color wheel based on traditional color theory (RYB), the complementary color to green is considered to be red.
The word green is closely related to the Old English verb growan, "to grow". It is used to describe plants or the ocean. Sometimes it can also describe someone who is inexperienced, jealous, or sick. In the United States of America, green is a slang term for money, among other things. Several colloquialisms have derived from these meanings, such as "green around the gills", a phrase used to describe a person who looks ill.
In a lonely railway station
There's a man who sits and wonders
If he ever will be going home again
And his eyes can still remember
As he sees the faded picture
Of the girl who said she'd always be his friend
So he lights another cigarette
And wonders if she'll ever get the message
In the letter that he sent
Chorus:
Lucy Brown,
We been so long apart now I'm cryin'
I'm goin' down
Though I'm tryin'
Feel I'm dyin'!
Lucy Brown
Now we're so far apart feel I'm sinkin',
Since I been gone
I been thinkin',
Can't help thinkin'
Of Lucy Brown
Well he hasn't got the money
To get back to the city,
So he sits alone and stares into the floor
Then he hears a whistle blowin'
As a train pulls in the station
And he looks up and she's standin' by the door
And she smiles at him so sweetly
As she's holdin' up the letter
And he looks at her and says to her once more
Chorus twice:
Lucy Brown,
We been so far apart now I'm cryin'
I been so down,
I was tryin',
I was dyin'
Lucy Brown,
We been so far apart I been sinkin'
Since I been gone
I been thinkin',
Can't help thinkin'