- published: 15 Feb 2012
- views: 47030
The free radical theory of aging (FRTA) states that organisms age because cells accumulate free radical damage over time. A free radical is any atom or molecule that has a single unpaired electron in an outer shell. While a few free radicals such as melanin are not chemically reactive, most biologically-relevant free radicals are highly reactive. For most biological structures, free radical damage is closely associated with oxidative damage. Antioxidants are reducing agents, and limit oxidative damage to biological structures by passivating them from free radicals.
Strictly speaking, the free radical theory is only concerned with free radicals such as superoxide ( O2− ), but it has since been expanded to encompass oxidative damage from other reactive oxygen species such as hydrogen peroxide (H2O2), or peroxynitrite (OONO−).
Denham Harman first proposed the free radical theory of aging in the 1950s, and in the 1970s extended the idea to implicate mitochondrial production of reactive oxygen species.
In chemistry, a radical (more precisely, a free radical) is an atom, molecule, or ion that has unpaired valence electrons. With some exceptions, these unpaired electrons make free radicals highly chemically reactive towards other substances, or even towards themselves: their molecules will often spontaneously dimerize or polymerize if they come in contact with each other. Most radicals are reasonably stable only at very low concentrations in inert media or in a vacuum.
A notable example of a free radical is the hydroxyl radical (HO•), a molecule that has one unpaired electron on the oxygen atom. Two other examples are triplet oxygen and triplet carbene (:CH
2) which have two unpaired electrons. In contrast, the hydroxyl anion (HO−
) is not a radical, since the unpaired electron is resolved by the addition of an electron; singlet oxygen and singlet carbene are not radicals as the two electrons are paired.
Free radicals may be created in a number of ways, including synthesis with very dilute or rarefied reagents, reactions at very low temperatures, or breakup of larger molecules. The latter can be affected by any process that puts enough energy into the parent molecule, such as ionizing radiation, heat, electrical discharges, electrolysis, and chemical reactions. Indeed, radicals are intermediate stages in many chemical reactions.
Aging is a "slow progression of oxidative stress," Much of oxidative stress comes from our toxic environment, poor diet, toxins in our diet, Smoking, Alcohol, stressful lifestyle, exposure to the sun and even exercise.... How are you taking control of your "Oxidative Stress" Levels?
This is the first video of our take on the Free Radical theory of aging. It is just a brief overview of the main concepts of this theory using a poster-teaching technique. Thanks for watching! Jordan Cochran Jana Coombs Ashley Crews Logan Geren
"Free Radical Theory of Aging and Oxidative Stress"
Aging Theories, What is Aging?, Telomere Theory, Free Radical Theory, Hormone Theory Aging genetic gerontology Sirtuin genes Sir2 cell repair Resveratrol telomerase Check out my new YouTube Channel, http://youtube.com/superhumannate. I'll upload at least 1 science tutorial video each week covering chemistry, electronics, computer science and more.
Free radical damage explained. Find out about the ONLY supplement in the world clinically proven to reduce oxidative stress and free radical damage by 40%, slowing down the rate of cell aging to the level of a 20 year old. All peer reviewed clinical studies can be found here: http://www.ncbi.nlm.nih.gov/pubmed/?term=protandim For more info, visit: http://www.nrf2science.com/ http://www.abcliveit.com/ YOU CAN PLACE YOUR ORDERS DIRECTLY AT: https://mylifevantage.com/sepincurtis
Check Out How To Stay Healthier: http://globalteampreview.com/brainfuel/?id=BayAreaBrainFuelTeam Our Corporate Website: http://bayareabrainfuelteam.brainabundance.biz/ It is estimated that as many as 80% of people around the world have some form of neurological challenge; whether it's something small like the inability to stay focused for long periods of time, something more serious like always feeling stressed out, anxious, depressed, or not able to sleep, or something much more severe like dementia or alzheimers. More Info: http://www.news-medical.net/news/20141119/Blocking-key-brain-receptor-cell-could-neutralize-biological-consequences-of-Alzheimers.aspx More Info: http://abcnews.go.com/Technology/wireStory/doctor-free-radical-aging-theory-dies-27169797 More Info: http://www.beta...
This is the second video of our take on the Free Radical theory of aging. It is just a brief overview of the main concepts of this theory using a visual aid-teaching technique. Thanks for watching! Jordan Cochran Jana Coombs Ashley Crews Logan Geren
Doctor Michael Greger shares Antioxidants vs Free Radicals and Oxidative Stress. Invite You to subscribe to my Video Channel: http://goo.gl/wdCj68 Video Source: http://NutritionFacts.org https://www.youtube.com/channel/UCddn8dUxYdgJz3Qr5mjADtA https://www.youtube.com/watch?v=lrPnRNX415o Licensed under: https://creativecommons.org/publicdomain/zero/1.0/deed.en CC0 1.0 Universal (CC0 1.0) Public Domain Dedication https://en.wikipedia.org/wiki/Antioxidant "is a molecule that inhibits the oxidation of other molecules. Oxidation is a chemical reaction that can produce free radicals, leading to chain reactions that may damage cells." https://en.wikipedia.org/wiki/Free-radical_theory_of_aging "The free radical theory of aging (FRTA) states that organisms age because cells accumulate free rad...
Low grade inflammation and free radical damage are risk factors for most chronic conditions and dementia is no exemption. https://tissuerecovery.com/brain/memory/dementia-inflammation-and-free-radical-damage/ References: Komulainen P1, Lakka TA, Kivipelto M, Hassinen M, Penttilä IM, Helkala EL, Gylling H, Nissinen A, Rauramaa R. Serum high sensitivity C-reactive protein and cognitive function in elderly women. Age Ageing. 2007 Jul;36(4):443-8. Epub 2007 May 30. Markesbery WR1, Lovell MA. Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment. Arch Neurol. 2007 Jul;64(7):954-6. Miralbell J1, López-Cancio E, López-Oloriz J, Arenillas JF, Barrios M, Soriano-Raya JJ, Galán A, Cáceres C, Alzamora M, Pera G, Toran P, Dávalos A, Mataró M. Cognitive patterns in relation to bio...
The free radical theory of aging goes back to the 1950s and Denham Harman. We have seen that the cells' metabolism and genetics includes extensive antioxidant capabilities. If these genes were near the telomeres, the antioxidant systems would gradually fail and the free radicals would destroy the cell providing an elegant termination of life. That aging is is programmed into our genes is not questioned, but specifics are not understood. two references http://www.ncbi.nlm.nih.gov/pubmed/20021368 http://www.ncbi.nlm.nih.gov/pubmed/11718765 My final comments https://app.box.com/s/16cj51lbvb5ubhgh91ezmixl8odzv6p2
The free radical theory of aging (FRTA) states that organisms age because cells accumulate free radical damage over time. A free radical is any atom or molecule that has a single unpaired electron in an outer shell. While a few free radicals such as melanin are not chemically reactive, most biologically-relevant free radicals are highly reactive. For most biological structures, free radical damage is closely associated with oxidative damage. Antioxidants are reducing agents, and limit oxidative damage to biological structures by passivating them from free radicals.
“FREDDY’S IN YOUR CORNER” Visit: http://www.yourhealthyjourney.org “FRED CLIFF NOTES” 1. Can fierce competition increase the aging process to free radical damage? (YES, POTENTIALLY) 2. Can we train hard and live life to its fullest? (YES, IF WE UNDERSTAND THE BODY) 3. How can we build the best approach to life? (BE OPEN MINDED) TIPS FROM FRED’S BOOK Your Healthy Journey Tip: “Making a commitment to healthy lifestyle changes is the key to optimal health.” Fred Bisci Activity Tip: The key to an optimal eating lifestyle is not jumping in and out of your parameters because vacillating puts a huge strain on the body and will express your genetic weaknesses, and we all have them! Longevity Tip: A small dose of faith, common sense, an open mind, ...
How can I reduce the free radical damage after exercise http://myrainlife.com/correctivebodyworks http://correctivebodyworks
How to reduce free radical damage
This video is posted by Tempol.info, a consortium of researchers dedicated to disseminating information on redox and Tempol. For more information, visit www.Tempol.info or inquire at info@Tempol.info. ___ http://tempol.info/ http://tempol.info
Free radicals are explained. Reactive oxygen species, superoxide dismutases, Glutathione, vitamins E, A, and C, and β-carotene, Lipid peroxidation of membranes, Cross-linking of proteins, and DNA fragmentation are also discussed. Visit http://www.abalancedlifechiro.com/resources/Videos/ for a more organized approach to watching these videos. Browse the Table of contents on the left for quick reference of videos.
Topics include: - Definition of Free Radical - Examples of Free Radicals - How Free Radicals Are Generated - How Free Radicals Are Removed - How Free Radicals Cause Cell Injury Hope it is helpful. - Dr. Rabiul Haque
Freshman Organic Chemistry (CHEM 125) Work by Wöhler and Liebig on benzaldehyde inspired a general theory of organic chemistry focusing on so-called radicals, collections of atoms which appeared to behave as elements and persist unchanged through organic reactions. Liebig's French rival, Dumas, temporarily advocated radicals, but converted to the competing theory of types which could accommodate substitution reactions. These decades teach more about the psychology, sociology, and short-sightedness of leading chemists than about fundamental chemistry, but both theories survive in competing schemes of modern organic nomenclature. The HOMO-LUMO mechanism of addition to alkenes and the SOMO mechanism of free-radical chain reactions are introduced. 00:00 - Chapter 1. Benzaldehyde and the Focu...
Dr Dan Murphy, DC whole-heartedly endorses Protandim and the science behind it. Research literature confirms the cause behind most chronic illnesses to be oxidative stress and free radical damage. Protandim has been proven to reduce oxidative stress in everyone that uses it.
Biohacking, nootropics, and the notion of optimizing one's human performance are on a rapid rise. Nootrobox founders Geoffrey Woo and Michael Brandt are some of the foremost thinkers in this space, and they are here to have intellectual conversations that will make you THINK. Episode 9 features Aubrey de Grey, the Chief Scientist Officer of the SENS Research Foundation. In this episode, Geoff, Michael, and Aubrey discuss the nuances of aging and health and their differing opinions and tactics of how to fully optimize these notions. Read more about Aubrey de Grey's mitochondiral theory: https://nootrobox.com/biohacker-guide/metabolism/the-mitochondrial-free-radical-theory-of-aging Nootrobox Twitter: twitter.com/nootrobox Nootrobox Instagram: www.instagram.com/nootrobox/ SUBSCRIBE for up...
University College, the professional and continuing education division in Arts & Sciences at Washington University in St Louis, hosts the MLA Lecture Series every Saturday in February from 11:00 - 12:30 in McDonnell Hall (Goldfarb Auditorium). Lectures are free and open to the public. Seating is limited. The Master of Liberal Arts (MLA) Saturday Lecture Series is sponsored by the Master of Liberal Arts program and University College. This year's MLA Lecture Series continues our consideration of values, turning out attention to "tolerance," and drawing upon perspectives from Classics, Law, Psychology and Literature to examine this crucial social and political virtue. February 9, 2013 Greg Magarian, Professor of Law "Radical Ideas and Constructive Discourse in Free Speech Theory"
Freshman Organic Chemistry (CHEM 125) After discussing the statistical basis of the law of mass action, the lecture turns to developing a framework for understanding reaction rates. A potential energy surface that associates energy with polyatomic geometry can be realized physically for a linear, triatomic system, but it is more practical to use collective energies for starting material, transition state, and product, together with Eyring theory, to predict rates. Free-radical chain halogenation provides examples of predicting reaction equilibria and rates from bond dissociation energies. The lecture concludes with a summary of the semester's topics from the perspective of physical-organic chemistry. 00:00 - Chapter 1. The Boltzmann Factor and Entropy Against Traditional Views on Society...
Website: http://www.sens.org Aubrey de Grey: http://tinyurl.com/7knmonn Facebook: https://www.facebook.com/agingreversed?ref=profile Aubrey de Grey (GB), Chief Science Officer & Co-Founder, SENS Research Foundation. Topic Leader: Stephen Sackur (GB) Presenter HARDtalk, BBC Broadcasting House. Aubrey David Nicholas Jasper de Grey is an English author and theoretician in the field of gerontology and the Chief Science Officer of the SENS Research Foundation. He is editor-in-chief of the academic journal Rejuvenation Research, author of The Mitochondrial Free Radical Theory of Aging (1999) and co-author of Ending Aging (2007). He is known for his view that medical technology may enable human beings alive today to live to lifespans far in excess of any existing authenticated cases. De Grey'...
Website: http://www.sens.org Aubrey de Grey: http://tinyurl.com/7knmonn Aubrey David Nicholas Jasper de Grey is an English author and theoretician in the field of gerontology and the Chief Science Officer of the SENS Research Foundation. He is editor-in-chief of the academic journal Rejuvenation Research, author of The Mitochondrial Free Radical Theory of Aging (1999) and co-author of Ending Aging (2007). He is known for his view that medical technology may enable human beings alive today to live to lifespans far in excess of any existing authenticated cases. De Grey's research focuses on whether regenerative medicine can thwart the aging process. He works on the development of what he calls "Strategies for Engineered Negligible Senescence" (SENS), a collection of proposed techniques to ...
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