PTEN-induced putative kinase 1 (PINK1) is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene.
It is thought to protect cells from stress-induced mitochondrial dysfunction. PINK1 activity causes the parkin protein to bind to depolarized mitochondria to induce autophagy of those mitochondria. PINK1 is processed by healthy mitochondria and released to trigger neuron differentiation. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson's disease.
PINK1 is synthesized as a 63000 Da protein which is often cleaved by PARL, between the 103-Alanine and the 104-Phenylalanine residues, into a 53000 Da fragment. PINK1 contains an N-terminal mitochondrial localization sequence, a putative transmembrane sequence, a Ser/Thr kinase domain, and a C-terminal regulatory sequence. The protein has been found to localize to the outer membrane of mitochondria, but can also be found throughout the cytosol. Experiments suggest the Ser/Thr kinase domain faces outward toward the cytosol, indicating a possible point of interaction with parkin.
i'm not sure who's fooling who here
as i'm watching your decay
we both know you could deflate
a 7 hurricane
seems like you and your tribe
decided you'd rewrite the law
segregate the mind
from body and soul
you give me yours
i'll give you mine
cause i can look your god
right in the eye
you give me yours
i'll give you mine
you used to look my god
right in the eye
i believe in defending
in what we once
stood for
it seems in vogue
to be a closet
misogynist homophobe
a change of course in
our direction
a dash of truth
spread thinly
like a flag
on a popstar
on a benzodiazapene
oh zion please
remove your glove
and dispel every
trace
of his spoken word
that has lodged
in my vortex
i'm not sure who's fooling who here
as i'm watching your decay
we both know you could deflate
a 7 hurricane
you could have spared
her - oh but no
messiahs need
people dying in their
name
you say "i ordered you a
pancake"
you say "i ordered you a
