- published: 17 Aug 2015
- views: 4310432
PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (disks large homolog 4) gene.
PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.
PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels.
10 Video Game Disc Facts You Probably Didn't Know
How Discs Fly - A Beginners Guide to Disc Golf
EATS EVERYTHING - Big Discs [Pets Recordings]
FRANCIS RAGE - NO MORE PHYSICAL DISCS
Rumor: Nintendo NX to Drop Discs for Cartridges - IGN News
HOW TO FIX YOUR DISCS! (MW2)
All 40 Series 2 Disney Infinity 2.0 Power Discs Gameplay (Dad & Daughter Commentary w/ Face Cam)
How to Change Front Brake Discs & Pads
Eats Everything - Big Discs
PS4 Won't Read Discs Fix (Makes Noise/Won't Accept Discs)
How to Choose Overstable vs. Understable Disc Golf Discs: TURN Explained (#2 of 4)
Will Schusterick Driving Clinic By Infinite Discs
February 1998
Today's emptiness, tomorrow's dream.
An addiction, like never seen.
All is still beneath an orange moon.
Everything remains, but without you.