CD1

CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T cells. However their precise function is unknown.

Types

CD1 glycoproteins can be classified primarily into two groups which differ in their lipid anchoring.

  • CD1a, CD1b and CD1c (group 1 CD1 molecules) are expressed on cells specialized for antigen presentation.
  • CD1d (group 2 CD1) is expressed in a wider variety of cells.

    • CD1e is an intermediate form, expressed intracellularly, the role of which is currently unclear.

    In humans

    Group 1

    Group 1 CD1 molecules have been shown to present foreign lipid antigens, and specifically a number of mycobacterial cell wall components, to CD1-specific T cells.

    Group 2

    The natural antigens of group 2 CD1 are not well-characterized, but a synthetic glycolipid, alpha-galactosylceramide, originally isolated from a compound found in a marine sponge, has strong biologic activity.

    Read more
    This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/CD1

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