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Scaling to Singles

Edit The Scientist 01 May 2016
If there’s anything the burgeoning field of single-cell biology has revealed in the past few years, it’s that each cell is unique. Even cells of the same type can vary significantly in their complement of expressed genes ... ISOLATING CELLS ... FOUR SINGLE-CELL RNA-SEQ TECHNIQUES ... scLVM is a handy way of dissecting the sources of variability, such as the stage of cell cycle a cell is in, from technical noise....

A Dark Night Is Good For Your Health

Edit IFL Science 29 Apr 2016
In the last decade or two it has become clear that the genes which control the endogenous circadian rhythm (the “clock genes”) also control a large part of our entire genome including genes for metabolism (how we process the food we eat), DNA damage response (how we are protected from toxic chemicals and radiation), and cell cycle regulation and hormone production (how our cells and tissues grow)....

Discovery of common principle for cancer-suppression a... (University of Tokyo)

Edit Public Technologies 26 Apr 2016
The international group also suggested that the evolution of cell-cycle genes might have occurred in the initial stage of multicellularity, preceding the evolution of genes for the differentiation of cellular functions ... Olson, 'The Gonium pectorale genome demonstrates cooption of cell cycle regulation during the evolution of multicellularity', Nature Communications7, Article number....

The key to feeling well rested isn’t just the amount of time you sleep

Edit Business Insider 26 Apr 2016
In the last decade or two it has become clear that the genes which control the endogenous circadian rhythm (the “clock genes”) also control a large part of our entire genome including genes for metabolism (how we process the food we eat), DNA damage response (how we are protected from toxic chemicals and radiation), and cell cycle regulation and hormone production (how our cells and tissues grow)....

Vpr-mediated HLTF degradation [Cell Biology]>

Edit PNAS 26 Apr 2016
Viruses often interfere with the DNA damage response to better replicate in their hosts. The human immunodeficiency virus 1 (HIV-1) viral protein R (Vpr) protein has been reported to modulate the activity of the DNA repair structure-specific endonuclease subunit (SLX4) complex and to promote cell cycle arrest. Vpr also interferes... ....

Subtle Changes in Just One Part of the Cell Can Trigger a Cascade of ‘Cellular Misadventures’ (Children's Research Institute)

Edit Public Technologies 20 Apr 2016
The seemingly small change can lead to a cascade of cellular misadventures since it comes at a crucial time, when dividing cells adopt specialized roles within the body becoming, for example, nerves, the heart, or muscles ... Exit from the cell cycle occurs, and cells stop dividing ... slowing of exit from cell cycle … slowing of exit from pluripotency programs … and poorly coordinated induction of terminal differentiation programs.'....

Subtle Changes in Just One Part of the Cell Can Trigger a Cascade of ‘Cellular Misadventures’ (Children's National Medical Center Inc)

Edit Public Technologies 20 Apr 2016
The seemingly small change can lead to a cascade of cellular misadventures since it comes at a crucial time, when dividing cells adopt specialized roles within the body becoming, for example, nerves, the heart, or muscles ... Exit from the cell cycle occurs, and cells stop dividing ... slowing of exit from cell cycle … slowing of exit from pluripotency programs … and poorly coordinated induction of terminal differentiation programs.'....

Onconova Announces Novel Dual Targeting of ARK5 and CDK4/6 by Pre-clinical Compound, ON 123300, in Presentation at 2016 American Association of Cancer Research (AACR) Annual Meeting (Onconova Therapeutics Inc)

Edit Public Technologies 20 Apr 2016
The studies revealed that both compounds could inhibit CDK4/6 but only ON 123300 targeted ARK5, a kinase that regulates cancer cell metabolism by increasing glutamine uptake ... Cyclin-dependent kinases 4 and 6, or CDK4/6, are enzymes that regulate cell cycle progression. These proteins are activated in response to mitogenic signaling and respond by driving cells into the DNA synthesis phase of the cell cycle ... Mol Cell Biol....

Pfizer Announces Positive Top-Line Results for Phase 3 PALOMA-2 Clinical Trial of IBRANCE® (palbociclib) (Pfizer Inc)

Edit Public Technologies 19 Apr 2016
Monitor complete blood count prior to starting IBRANCE, at the beginning of each cycle, on Day 14 of first 2 cycles, and as clinically indicated. Dose interruption, dose reduction, or delay in starting treatment cycles is recommended for patients who develop Grade 3 or 4 neutropenia ... IBRANCE is an oral inhibitor of CDKs 4 and 6, which are key regulators of the cell cycle that trigger cellular progression....

Asynchronous cell cycle phase key to critical stage of animal embryonic development

Edit Science Daily 18 Apr 2016
The synchronous mitosis of early embryonic development switches to a patterned form at the 11th cell division following removal of a cell cycle compensatory mechanism, new research shows. An asynchronous S-phase length is masked by a compensatory asynchronous G2-phase length up to the 11th mitosis, after which the transition to spatial patterning occurs ... ....

AstraZeneca Presents DNA Damage Response Science at the AACR 2016 Annual Meeting

Edit Stockhouse 18 Apr 2016
... initial data is on cell cycle disruption and double-strand break repair2,3,5,6 ....

Cyclacel's Second-Generation CDK2/9 Inhibitor, CYC065, is an Effective Inducer of Cell Death in B-cell Lymphoma ...

Edit Stockhouse 18 Apr 2016
The data show that CYC065 can induce cell death and combined beneficially with anti-cancer drugs from the Bcl-2 and BET inhibitor classes, in in vitro models of B-cell lymphoma, including double-hit lymphomas ... Cyclacel is a biopharmaceutical company developing oral therapies that target the various phases of cell cycle control for the treatment of cancer and other serious diseases....

Cyclacel's Second-Generation CDK2/9 Inhibitor, CYC065, is an Effective Inducer of Cell Death in B-cell Lymphoma and Synergizes With Bcl-2 or BET Inhibitors (Cyclacel Pharmaceuticals Inc)

Edit Public Technologies 18 Apr 2016
The data show that CYC065 can induce cell death and combined beneficially with anti-cancer drugs from the Bcl-2 and BET inhibitor classes, in in vitro models of B-cell lymphoma, including double-hit lymphomas ... Cyclacel is a biopharmaceutical company developing oral therapies that target the various phases of cell cycle control for the treatment of cancer and other serious diseases....
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