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New culture system shows early toxicity to dendritic spines

Edit Science Daily 27 May 2016
Prion diseases are fatal and incurable neurodegenerative conditions of humans and animals. Yet, how prions kill nerve cells (or neurons) remains unclear. A new study describes a system in which to study the early assault by prions on brain cells of the infected host ... ....

How prions kill neurons: new culture system shows early toxicity to dendritic spines (Boston University)

Edit Public Technologies 26 May 2016
Prion diseases are fatal and incurable neurodegenerative conditions of humans and animals. Yet, how prions kill nerve cells (or neurons) remains unclear. A study published on May 26 in PLOS Pathogens describes a system in which to study the early assault by prions on brain cells of the infected host ... And indeed, the researchers found that these neurons-just like neurons without any PrP-were immune to prion toxicity....

Prion proteins in plants [Plant Biology]>

Edit PNAS 24 May 2016
Prion proteins provide a unique mode of biochemical memory through self-perpetuating changes in protein conformation and function. They have been studied in fungi and mammals, but not yet identified in plants. Using a computational model, we identified candidate prion domains (PrDs) in nearly 500 plant proteins. Plant flowering is of... ....

Unsafe at Any Dose: Chemical Safety Failures from DDT to Glyphosate to BPA

Edit CounterPunch 24 May 2016
Piecemeal, and at long last, chemical manufacturers have begun removing the endocrine-disrupting plastic (BPA) from products they sell ... France has a on BPA food packaging. The ... ) ... Following the UK’s traumatically disastrous outbreak of BSE (mad cow disease) in the 1980s, during which most of the UK population was exposed to infectious prions following highly questionable scientific advice, this exact recommendation was made in ... )....

Are there prions in plants? [Commentaries]>

Edit PNAS 23 May 2016
Self-perpetuating protein conformers (prions) have been described in animals (including human) and fungi (including yeast), and linked to both diseases and heritable traits (1–4). One would wonder if plants have them too. Indeed, a paper by Chakrabortee et al. (5), from the laboratory of Susan Lindquist, provides a first example... ....

Ex-Massey Energy CEO Blankenship asks for delay in prion start

Edit Pittsburgh Post-Gazette 11 May 2016
CHARLESTON, W.Va. — Attorneys for former coal executive Don Blankenship want to delay his entry into prison this week ... ....

ProMIS Neurosciences announces first quarter 2016 results (ProMIS Neurosciences Inc)

Edit Public Technologies 11 May 2016
This on going program will seek to validate that the lead products selectively bind to the neurotoxic prion, or oligomeric form of Aβ, which the Company believes is the target product profile for successful precision therapies in these diseases....

USF Professor Studying Relationship Between Causes of Alzheimer’s and CTE, a Disease Found in Athletes with Head Injuries (University of South Florida)

Edit Public Technologies 09 May 2016
(Source. University of South Florida) ... Photo by Aimee Blodgett. TAMPA, Fla ... Muschol, who recently received a three-year, $440,000 grant renewal from the National Institutes of Health to continue his work on the causes of Alzheimer's, compares the concept of a CTE 'seed' spreading within the damaged brain to 'prion diseases,' a set of diseases in which damaged protein can transmit its damaged state to its healthy counterpart in the brain....

This couple gave up their careers to train as scientists and find a cure for her rare genetic disease

Edit Quartz 06 May 2016
Sonia is 32 and her inherited genetic condition, called fatal familial insomnia, usually strikes people in their 50s ... These mutant proteins, called prions, collect in the brain and cause severe insomnia leading to death ... ....

Attorneys fight against Abu-Rayyan’s exam location

Edit Detroit news 06 May 2016
Attorneys for a 21-year-old Dearborn Heights man have filed an emergency appeal to block federal authorities from transporting him nearly 700 miles away for a mental health evaluation. Khalil Abu-Rayyan has been in federal detention since Feb. 16 after a grand jury in Detroit indicted him on two gun-related felonies ... Last month, U.S ... Rayyan’s attorneys, Todd Shanker and Benton C ... Bureau of Prions for all federal detainees ... ....

Aggregated protein in nerve cells can cause ALS (Umeå universitet)

Edit Public Technologies 04 May 2016
(Source. Umeå universitet). Aggregated protein in nerve cells can cause ALS. [2016-05-04] Persons with the serious disorder ALS, can have a genetic mutation that causes the protein SOD1 to aggregate in motor neurons in the brain and spinal cord ... The discovery has been described in the Journal of Clinical Investigation ... About the publication. ... Two superoxide dismutase prion strains transmit amyotrophic lateral sclerosis-like disease ... DOI....

ProMIS Neurosciences, Inc. Successfully Completes CDN $1.0 Million Private Placement (ProMIS Neurosciences Inc)

Edit Public Technologies 04 May 2016
(Source. ProMIS Neurosciences Inc). ProMISNeurosciences, Inc. NEWS RELEASE TSX. PMN. FOR IMMEDIATE RELEASE ... ProMIS Neurosciences, Inc. Successfully Completes CDN $1.0 Million Private Placement ... This program is designed to validate that the lead mab products selectively bind to the neurotoxic prion, or oligomeric form of Aβ, which the Company believes is the target product profile for successful precision therapies in these diseases ... Dr ... Tel....

Mechanical prion and long-term memory [Chemistry]>

Edit PNAS 03 May 2016
Aplysia cytoplasmic polyadenylation element binding (CPEB) protein, a translational regulator that recruits mRNAs and facilitates translation, has been shown to be a key component in the formation of long-term memory. Experimental data show that CPEB exists in at least a low-molecular weight coiled-coil oligomeric form and an amyloid fiber form... ....
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