"Best of You" is a song by American alternative rock band Foo Fighters, and the first single released from the band's fifth studio album, In Your Honor. Dave Grohl notes that the song was written following appearances at 2004 American presidential candidate John Kerry's campaign trail and is "about breaking away from the things that confine you." To date, it is the band's only single to reach Platinum status in the US. The song holds the band's highest chart peaks in the US (#18), the UK (#4), and Australia (#5), and was nominated for a Grammy Award for Best Rock Song. The song won the Kerrang! Award for Best Single. It also topped Billboard's Hot Mainstream Rock Tracks chart for four weeks and Hot Modern Rock Tracks chart for seven weeks. Following the band's performance at Live Earth, the song again entered the UK charts at #38.

In an interview discussing the band's successful singles, Dave Grohl notes that: "Best of You is funny because we demoted so many songs for In Your Honor, I'd kind of forgotten about it. Our manager came in and said, "What happened to that Best of You song?" So we pulled it out and worked on it a little more."

A greatest hits album, sometimes called a best of album or a catalog album, is a compilation of songs by a particular artist or band. Most often the track list contains previously released recordings with a high degree of notability. However to increase the appeal, especially to people who already own the original release, it is common to include remixes and/or alternate takes of popular songs; even new material (previously unreleased). At times a greatest hits compilation is the original release for songs that have themselves been released as a single and charted successfully.

Madonna's The Immaculate Collection is the best selling greatest hits compilation by a solo artist; all of the songs on it are presented in different versions than the original hit versions. The Eagles' Their Greatest Hits (1971–1975) is the best selling greatest hits compilation by a group and also one of the ten best selling albums in history. Johnny Mathis's Johnny's Greatest Hits (1958) is generally considered the first greatest hits album. It was popular, remaining on the Billboard Top Albums Chart for a then record-breaking 490 continuous weeks. Greatest hits albums are typically produced after an artist has had enough successful songs to fill out an album release. Some artists, such as Michael Jackson, The Beatles, Kenny Rogers, Aerosmith, Kiss, U2, Los Tigres del Norte, Queen and Billy Joel, have released multiple greatest hits albums through their careers. Some greatest hits albums are released only at the end of the artist or group's career. Creed released a greatest hits album after they disbanded.