The Seminole Wars, also known as the Florida Wars, were three conflicts in Florida between the Seminole — the collective name given to the amalgamation of various groups of native Americans and Black people who settled in Florida in the early 18th century — and the United States Army. The First Seminole War was from 1814 to 1819 (although sources differ), the Second Seminole War from 1835 to 1842, and the Third Seminole War from 1855 to 1858.

The first conflict with the Seminole arose out of tensions relating to General Andrew Jackson's attack and destruction of Negro Fort in Florida in 1816. Jackson also attacked the Spanish at Pensacola. Ultimately, the Spanish Crown ceded the colony to United States rule.

The indigenous peoples of Florida declined significantly in number after the arrival of Europeans in the region. The Native Americans had little resistance to diseases newly introduced from Europe. Spanish suppression of native revolts further reduced the population in northern Florida. By 1707, colonial soldiers from the Province of Carolina and their Yamasee Indian allies had killed or carried off nearly all the remaining native inhabitants, having conducted a series of raids extending the full length of the peninsula. In the first decade of the 18th century, 10,000 – 12,000 Indians were taken as slaves according to the governor of La Florida and by 1710, observers noted that north Florida was virtually depopulated. The few remaining natives fled west to Pensacola and beyond or east to the vicinity of St. Augustine; in 1763, when Spain ceded Florida to Great Britain as part of the Treaty of Paris, the Spanish took the few surviving Florida Indians with them to Cuba and New Spain.

The Seminole are a Native American people originally of Florida, who now reside primarily there and in Oklahoma. The Seminole nation emerged in a process of ethnogenesis out of groups of Native Americans, most significantly Creek from what is now Georgia and Alabama, who settled in Florida in the early 18th century. The word Seminole is a corruption of cimarrón, a Spanish term for "runaway" or "wild one", historically used for certain Native American groups in Florida. The Seminole are closely related to the Miccosukee, who were recognized as a separate tribe in 1962.

After an initial period of colonization in Florida, during which they distanced themselves increasingly from other Creek groups, the Seminole established a thriving trade network during the British and second Spanish periods (roughly 1767–1821). The tribe expanded considerably during this time, and was further supplemented from the late 18th century with the appearance of the Black Seminoles – free blacks and escaped slaves who settled in communities near Seminole towns, where they paid tribute to the Native Americans in exchange for protection. However, tensions grew between the Seminole and the United States to the north, leading to a series of conflicts known as the Seminole Wars (1818–1858). Over the course of the wars most Seminoles were forced to relocate west of the Mississippi River in a process of Indian removal. Perhaps fewer than 200 Seminoles remained in Florida, but those who did fostered a resurgence in traditional customs and a culture of staunch independence.

The Black Seminoles is a term used by modern historians for the descendants of free blacks and some runaway slaves (maroons), mostly Gullahs who escaped from coastal South Carolina and Georgia rice plantations into the Spanish Florida wilderness beginning as early as the late 17th century. By the early 19th century, they had often formed communities near the Seminole Indians.

Together, the two groups formed a multi-ethnic and bi-racial alliance. Today, Black Seminole descendants still live in Florida, rural communities in Oklahoma and Texas, and in the Bahamas and Northern Mexico. In the 19th century, the Florida "Black Seminoles" were called "Seminole Negroes" by their white American enemies and Estelusti (Black People), by their Indian allies. Modern Black Seminoles are known as "Seminole Freedmen" in Oklahoma, "Black Indians" in the Bahamas, and Mascogos in Mexico. The Black Seminole Scouts served in the United States Army during the 19th century.

The Spanish strategy for defending their claim of Florida at first was based on organizing the indigenous people into a mission system. The mission Native Americans were to serve as militia to protect the colony from English incursions from the north. But a combination of raids by South Carolina colonists and new European infectious diseases, to which they did not have immunity, decimated Florida's native population. After the local Native Americans had all but died out, Spanish authorities encouraged renegade Native Americans and runaway slaves from England's southern colonies to move south. The Spanish were hoping that these traditional enemies of the English would prove effective in holding off English expansion.