Fatty Acid Synthesis (Part 2 of 12) - Transport of Acetyl CoA From Mitochondria to Cytosol

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• published: 17 Nov 2014
• views: 12524

In this video, I talk about acetyl CoA molecules are transported from the mitochondria out into the cytosol so as to allow for fatty acid synthesis to occur, since it occurs in the cytoplasm, not the mitochondrial matrix, like beta oxidation does. Acetyl CoA and Oxaloacetate both cannot cross the mitochondrial membrane(s). However, when the two join together and become citrate (citrate synthase from the TCA cycle catalyzes this), citrate can cross the mitochondrial membrane. Once the citrate is out in the cytosol, it can be cleaved back into oxaloacetate and acetyl CoA by citrate lyase. The oxaloacetate can be converted to malate, which is converted into pyruvate by an oxidative decarboxylation reaction catalyzed by malic enzyme. The pyruvate can cross the mitochondria membrane to get back into the mitochondria to be converted into oxaloacetate, which can join another acetyl CoA to allow the process to repeat and send as many acetyl coa molecules into the cytosol as necessary. I also discuss how many NADPH molecules will be needed and where they come from - from the malic enzyme reaction and from the glucose 6 phosphate dehydrogenase reaction from the pentose phosphate pathway. For a suggested viewing order of the videos, information on tutoring, and an opportunity to support me with donations, visit my website at the link below. Moof University Website: www.MoofUniversity.com