Nuclear MASINT is one of the six major subdisciplines generally accepted to make up Measurement and Signature Intelligence (MASINT), which covers measurement and characterization of information derived from nuclear radiation and other physical phenomena associated with nuclear weapons, reactors, processes, materials, devices, and facilities. Nuclear monitoring can be done remotely or during onsite inspections of nuclear facilities. Data exploitation results in characterization of nuclear weapons, reactors, and materials. A number of systems detect and monitor the world for nuclear explosions, as well as nuclear materials production.

According to the United States Department of Defense, MASINT is technically derived intelligence (excluding traditional imagery IMINT and signals intelligence SIGINT) that – when collected, processed, and analyzed by dedicated MASINT systems – results in intelligence that detects, tracks, identifies, or describes the signatures (distinctive characteristics) of fixed or dynamic target sources. MASINT was recognized as a formal intelligence discipline in 1986. Materials intelligence is one of the major MASINT disciplines (FM2-0Ch9).