Paleobiology (sometimes spelled palaeobiology) is a growing and comparatively new discipline which combines the methods and findings of the natural science biology with the methods and findings of the earth science paleontology. It is occasionally referred to as "geobiology".

Paleobiological research uses biological field research of current biota and of fossils millions of years old to answer questions about the molecular evolution and the evolutionary history of life. In this scientific quest, macrofossils, microfossils and trace fossils are typically analyzed. However, the 21st-century biochemical analysis of DNA and RNA samples offers much promise, as does the biometric construction of phylogenetic trees.

An investigator in this field is known as a paleobiologist.

The founder or "father" of modern paleobiology was Baron Franz Nopcsa (1877 to 1933), a Hungarian scientist trained at the University of Vienna. He initially termed the discipline "paleophysiology."

However, credit for coining the word paleobiology itself should go to Professor Charles Schuchert. He proposed the term in 1904 so as to initiate "a broad new science" joining "traditional paleontology with the evidence and insights of geology and isotopic chemistry."