The University of San Francisco (USF) is a private, Jesuit/Catholic university located in San Francisco, California, United States. Founded in 1855, USF was established as the first university in San Francisco. It is the second oldest institution for higher learning in California and the tenth-oldest university of the Association of Jesuit Colleges and Universities. USF is the eighth largest Jesuit university in the United States.

USF's main campus is located on a 50-acre (20 ha) setting between the Golden Gate Bridge and Golden Gate Park. USF's nickname is "The Hilltop," appropriate since the campus is located at the peak of one of San Francisco's major hills. USF's close historical ties with the City and County of San Francisco are reflected in the University's motto, Pro Urbe et Universitate (For the City and University).

USF's Jesuit-Catholic identity is rooted in the symbolic vision of St. Ignatius of Loyola, the founder of the Jesuit order. Jesuits are characterized by a dedication to both "the life of the mind and the encounter with the world," a mission distinguished by their intellectual and humanitarian activities — notably in the fields of higher education, human rights, and social justice.

San Francisco (/ˌsæn frənˈsɪskoʊ/), officially the City and County of San Francisco, is the financial, cultural, and transportation center of the San Francisco Bay Area, a region of 7.6 million people which includes San Jose and Oakland. The only consolidated city-county in California, it encompasses a land area of about 46.9 square miles (121 km²) on the northern end of the San Francisco Peninsula, giving it a density of about 17,179 people per square mile (6,632 people per km²). It is the most densely settled large city (population greater than 200,000) in the state of California and the second-most densely populated large city in the United States after New York City. San Francisco is the fourth most populous city in California and the 13th most populous city in the United States, with a population of 805,235 as of the 2010 Census. The San Francisco-Oakland-Fremont metropolitan area has a population of 4,335,391.

In 1776, colonists from Spain established a fort at the Golden Gate and a mission named for Francis of Assisi a few miles away. The California Gold Rush of 1849 propelled the city into a period of rapid growth, increasing the population in one year from 1,000 to 25,000, and thus transforming it into the largest city on the West Coast at the time. After three-quarters of the city was destroyed by the 1906 earthquake and fire, San Francisco was quickly rebuilt, hosting the Panama-Pacific International Exposition nine years later. During World War II, San Francisco was the port of embarkation for service members shipping out to the Pacific Theater. After the war, the confluence of returning servicemen, massive immigration, liberalizing attitudes, and other factors led to the Summer of Love and the gay rights movement, cementing San Francisco as a center of liberal activism in the United States.