- published: 06 Sep 2016
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An HIV vaccine is a vaccine which would either protect individuals who do not have HIV from contracting that virus, or otherwise may have a therapeutic effect for persons who have or later contract HIV/AIDS. Currently, there is no effective HIV vaccine but many research projects managing clinical trials seek to create one. There is evidence that a vaccine may be possible. Work with monoclonal antibodies (MAb) has shown or proven that the human body can defend itself against HIV, and certain individuals remain asymptomatic for decades after HIV infection. Potential candidates for antibodies and early stage results from clinical trials have been announced.
One HIV vaccine candidate which showed some efficacy was studied in RV 144, which was a trial in Thailand beginning in 2003 and first reporting a positive result in 2009. Many trials have shown no efficacy, including the STEP study and HVTN 505 trials.
The urgency of the search for a vaccine against HIV stems from the AIDS-related death toll of over 25 million people since 1981. Indeed, in 2002, AIDS became the primary cause of mortality due to an infectious agent in Africa.
A lecture by Dan Barouch, professor of medicine at Harvard Medical School and director of the Center for Virology and Vaccine Research at Beth Israel
HIV & hepatitis tainted blood products were in the system before proper screening was introduced in the mid-1980s & then companies had voluntary agreed to withdraw the old medicine based on large pools of donated plasma in favor of "safer" heat treated versions but the FDA approved selling it to people over seas & companys like Cutter were dumping tainted" medicine into other countries Harry M. Meyer Jr. the FDA's regulator of blood products asked that the issue be "quietly solved without alerting the Congress, the medical community and the public" , the FDA wanted the matter solved "quickly and quietly." clotting producers quietly settled many claims. most states had laws shielding blood products from traditional product liability claims Individual lawsuits continued to fail ...
Dan Barouch, M.D., Ph.D., is director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center. He is also a professor of medicine at Harvard Medical School. In addition, he is a key part of the Bill & Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery, the National Institutes of Health Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, and the Ragon Institute of MGH, MIT, and Harvard. Dr. Barouch received his Ph.D. in immunology from Oxford University and his M.D. from Harvard Medical School. His laboratory focuses on studying the immunology and virology of HIV-1 infection and developing novel vaccine strategies. His laboratory has explored a series of novel vaccine technologies, including adjuvanted DNA vaccines, poxvirus ...
Researchers at the HIV Vaccine Trials Network are working toward the goal of welcoming an AIDS-free generation - and they're doing it by developing an effective, global HIV vaccine. Through clinical trials at sites all over the world, efforts are focused on a successful Thai trial, called RV144, which recently provided renewed optimism that the scientific-underpinnings for an HIV Vaccine are coming closer to a reality. And what's amazing is that most of their work wouldn't be possible without the help of volunteers. If you want to live in a world that is free from HIV, free from AIDS . . . then get involved!
What is HIV VACCINE? What does HIV VACCINE mean? HIV VACCINE meaning, definition & explanation. An HIV vaccine is a vaccine which would either protect individuals who do not have HIV from contracting that virus, or otherwise may have a therapeutic effect for persons who have or later contract HIV/AIDS. Currently, there is no effective HIV vaccine but many research projects managing clinical trials seek to create one. There is evidence that a vaccine may be possible. Work with monoclonal antibodies (MAb) has shown or proven that the human body can defend itself against HIV, and certain individuals remain asymptomatic for decades after HIV infection. Potential candidates for antibodies and early stage results from clinical trials have been announced. One HIV vaccine candidate which showe...
NIAID Director Anthony S. Fauci, M.D., discusses challenges and progress in HIV vaccine development at the 21st International AIDS Conference in Durban, South Africa. (Video courtesy of the International AIDS Society.)
One of the main mysteries confounding development of an HIV vaccine is why some people infected with the virus make the desired antibodies after several years, but a vaccine can’t seem to induce the same response. A research team led by scientists at the Duke Human Vaccine Institute has been unraveling that mystery, detailing new insights in a study published July 29 in the journal Science Immunology. Studying 100 HIV-infected people -- half whose immune systems eventually made antibodies capable of broadly neutralizing the virus and half whose immune systems did not -- the researchers found several key immune differences that should help in the development of a how-to manual for an effective vaccine. “This work gives us the beginning of an understanding of the immune mechanisms that...
Towards an HIV Vaccine: A Scientific Journey The following is the opening keynote address delivered via video by Dr. Anthony S. Fauci of NIAID, National Institutes of Health on March 23, 2015 at the Keystone Symposia joint meetings on “HIV Vaccines” and “The Golden Anniversary of B Cell Discovery” in Banff, Alberta, Canada. Dr. Fauci was unable to attend in person due to his work caring for an Ebola patient at the NIH Clinical Center in Bethesda, Maryland. About Anthony S. Fauci (from NIH Site): Dr. Fauci was appointed Director of NIAID in 1984. He oversees an extensive research portfolio of basic and applied research to prevent, diagnose, and treat infectious diseases such as HIV/AIDS and other sexually transmitted infections, influenza, tuberculosis, malaria and illness from potential ...
HIV continues to be the epidemic of our lifetime. Even today, 2 million new infections occur worldwide and there are over 50,000 new cases a year in the US. Developing an HIV vaccine has been a scientific challenge, but new technologies and approaches are leading to guarded optimism about achieving this goal. Dr. Lawrence Corey, professor of medicine and laboratory medicine at the University of Washington, past president of the Fred Hutchinson Cancer Research Center, and head of the HIV Vaccine Trials Network, will discuss the state of the HIV vaccine field and the role Seattle plays in this field. Lawrence Corey, MD, professor, Departments of Medicine and Laboratory Medicine, adjunct professor, Departments of Pediatrics and Microbiology, University of Washington 03/30/2016 http://depts...
Barbara Loe Fisher of the National Vaccine Information Center discusses the growing controversy over vaccines, including the alleged link to the epidemic of autism. Will Obamacare mandate vaccines? What about an HIV/AIDS vaccine? Please go to www.nvic.org and America's Survival, Inc., ASI, (www.usasurvival.org) for more information. ASI has been fighting against a mandatory HIV/AIDS vaccinefor ovr a decade. The AIDS vaccine will be first tried on children, whose immune systems are not fully developed. The elderly and those who are already sick with AIDS may get even weaker or sicker after exposure to an AIDS vaccine. On the other hand, a healthy immune system exposed to the vaccine may induce AIDS itself. A vaccine may spread the disease to more people. Help us stop this vaccine madness.
Presentation Title: "HIV Vaccine Research Update: Where Do We Stand in 2014?" Event Date: Friday, May 2, 2014 Guest Speaker: Magdalena Sobieszczyk, MD, MPH is an Associate Professor of Medicine in the Infectious Diseases Division at the Columbia University College of Physicians and Surgeons. She is also the Principal Investigator of the NIH-funded Columbia HVTN and ACTG Clinical Research Site. Her research focuses on developing, testing, and implementation of biomedical strategies to prevent HIV infection, specifically preventive HIV vaccines and pre-exposure prophylaxis (PrEP). Particular interests include assessing combination biomedical prevention strategies such as vaccines together with oral and topical PrEP. Host Institution: Albany Medical College, Division of HIV Medicine; bro...
In this informative talk, Bruce Walker, investigator for the Howard Hughes Medical Institute and director for the Center for AIDS research, discusses efforts to develop an effective vaccine against HIV. Despite decades of research, scientists have not closed in on developing a much-needed vaccine for HIV. A key challenge is how to address the rapid evolution of the virus within individuals, which makes it difficult to pinpoint a stable protein sequence for vaccine development.
http://www.ted.com Seth Berkley explains how smart advances in vaccine design, production and distribution are bringing us closer than ever to eliminating a host of global threats -- from AIDS to malaria to flu pandemics. TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes. Featured speakers have included Al Gore on climate change, Philippe Starck on design, Jill Bolte Taylor on observing her own stroke, Nicholas Negroponte on One Laptop per Child, Jane Goodall on chimpanzees, Bill Gates on malaria and mosquitoes, Pattie Maes on the "Sixth Sense" wearable tech, and "Lost" producer JJ Abrams on the allure of mystery. TED stands for Technology, Entertainment, Des...
Professor Linda-Gail Bekker is the Deputy Director of the Desmond Tutu HIV Centre, Chief Operating Officer at the Desmond Tutu HIV Foundation and Professor of Medicine at the University of Cape Town. She is also President-elect of the International AIDS Society. Amongst many HIV prevention research activities that she leads, she is the principal investigator of the HVTN 100 vaccine trial, and in this webinar she discussed the latest in HIV vaccine research and the most recent updates on the plan to start a new vaccine efficacy trial later this year.
Biomedical research towards the prevention and treatment of HIV, tuberculosis, malaria, and other major global health challenges remains our long-term hope for bringing these epidemics to an end. Understanding when new technologies are likely to emerge from the research and development pipeline, and how they might impact ongoing efforts, is vital to ensuring their rapid uptake and integration. Please join us for a discussion on the status of HIV vaccines and how the U.S. will need to change its response to the global epidemic. Dr. Anthony Fauci, Director of the National Institute of Allergy and Infectious Disease (NIAID), will deliver the keynote address. Afterwards, Dr. Fauci will join a distinguished panel with Mr. Mitchell Warren, Executive Director of AVAC, a New York-based advocacy...
HIV Vaccine and Prevention Technologies: Forging a Path Forward This session featured Drs. Marc Gurwith and Frank Plummer. Replication Competent Vector Vaccine for HIV: Development of an Orally Administered Replication-competent Adenovirus Serotype 4 Vector Vaccine Candidate for HIV Marc Gurwith is Chief Medical Officer at PaxVax. He is a Fellow of the Infectious Disease Society of America, and is currently a member of The Brighton Collaboration Viral Vaccine Vector Safety Working Group and the Scientific Advisory Board for the Keystone Symposia. Towards New Technologies for HIV Prevention Frank Plummer is a Senior Advisor to the Chief Public Health Officer, the Agency Deputy Head of the Public Health Agency of Canada and a Distinguished Professor at the University of Manitoba.