Question of fact

In law, a question of fact, also known as a point of fact, is a question which must be answered by reference to facts and evidence, and inferences arising from those facts. Such a question is distinct from a question of law, which must be answered by applying relevant legal principles. The answer to a question of fact (a "finding of fact") is usually dependent on particular circumstances or factual situations.

To illustrate the difference:

After hearing evidence, a U.S. court may issue a "Findings of Fact and Conclusions of Law," which separately examines the factual issues and then draws a legal conclusion. In the above example, the court might write that the facts have been established to a required standard of proof that Mr. and Mrs. Jones left their 10 year old child home alone with a baby for several days. The conclusion of law would then follow, outlining the given child neglect statute that Mr. and Mrs. Jones violated.

FACT (biology)

FACT (facilitates chromatin transcription) is a heterodimeric protein complex that affects eukaryotic RNA polymerase II (Pol II) transcription elongation both in vitro and in vivo. It was discovered in 1998 as a factor purified from human cells that was essential for productive in vitro Pol II transcription on a chromatinized DNA template.

FACT consists of 140 and 80 kilodalton (kDa) subunits. The 140 kDa subunit is encoded by a human gene (SUPT16H) which is 36% identical to the S. cerevisiae gene Spt16 and the 80 kDa subunit is human SSRP1 (POB3 in S. cerevisiae). Both of these subunits in yeast affect Pol II transcription elongation, and purified human FACT binds specifically to mononucleosomes and the histone H2A/H2B dimer, but not to the H3/H4 tetramer (see: Nucleosome core particle) or Pol II.

Co-immunoprecipitation assays with tagged recombinant proteins showed that the Spt16 subunit interacts with H2A/H2B dimers and mononucleosomes, but not H3/H4 tetramers, whereas the SSRP1 subunit interacts only with H3/H4 tetramers and not mononucleosomes. Deletion of the highly acidic carboxy-terminus of Spt16 (a common feature of known histone chaperones) does not prevent Spt16 from forming a stable complex with SSRP1, but it does eliminate interaction with mononucleosomes and ability to stimulate in vitro transcription on chromatinized templates. The two subunits together, but neither alone, can stimulate formation of nucleosomes from free histones and DNA (histone chaperone activity). These two subunits are highly conserved across all eukaryotes, and in addition to transcription, have been shown to affect DNA repair and replication as well.

Fact 2002

Fact 2002 was a 12 inch record released by the pop group Bis, paying tribute to Factory Records. The EP was given a low-key release.

It features covers of Joy Division's biggest hit "Love Will Tear Us Apart" (1980), New Order's B-side "Hurt" which was released with "Temptation" (1982), the debut single of A Certain Ratio "Shack Up" (1980) and "Looking from a Hilltop" from Section 25, which originally appeared on From the Hip (1984).

Track listing

References

Man (Middle-earth)

In J. R. R. Tolkien's Middle-earth books, such as The Hobbit and The Lord of the Rings, the terms Man and Men refer to humankind – in contrast to Elves, Dwarves, Orcs and other humanoid races – and does not denote gender.

The Elves call the race of Men Atani in Quenya, literally meaning "Second People" (the Elves being the First), but also Hildor (Followers), Apanónar (After-born), and Fírimar or Firyar (Mortals). Less charitably they were called Engwar (The Sickly), owing to their susceptibility to disease and old age, and their generally unlovely appearance in the Elves' eyes. The name Atani becomes Edain in Sindarin, but this term is later applied only to those tribes of Men who are friendly to the Elves. Other names appear in Sindarin as Aphadrim, Eboennin, and Firebrim or Firiath.

Origins

The race of Men is the second race of beings created by the One God, Ilúvatar. Because they awoke at the start of the Years of the Sun, while the Elves awoke at the start of the First Age during the Years of the Trees, they are called the Afterborn by the Elves.

Man (Francis Dunnery album)

Man is an album from British musician Francis Dunnery, released in 2001. It saw Francis experimenting with new sounds, most notably programmed drum beats - a departure from what had been the norm in his studio work up to this point. Vocalist/keyboardist Erin Moran (of A Girl Called Eddy) features heavily on the album.

Track listing

References

Manú (footballer)

Emanuel Jesus Bonfim Evaristo (born 28 August 1982), known as Manú, is a Portuguese professional footballer who plays mainly as a right winger.

Club career

Born in Setúbal, Manú started his professional career in the 2001–02 season playing for F.C. Alverca, before signing for S.L. Benfica in 2004 on a four-year contract. He was immediately loaned after arriving, serving stints in Italian sides Modena F.C. and A.C. Carpenedolo to gain experience, and returned to Portugal in the 2005–06 campaign for another temporary spell with C.F. Estrela da Amadora, where he played in 31 league games and scored seven goals, contributing to the preservation of the side's first division status.

In June 2006 Manú was given a new four-year deal and made his official debut for the Eagles by playing in both legs of the UEFA Champions League third qualifying round win against FK Austria Wien, also making a substitute appearance for Benfica in the group stages against F.C. Copenhagen, on 13 September 2006 (0–0 away draw).