D16, D.XVI or D-16 may refer to:

• Fokker D.XVI, a 1929 Dutch fighter aircraft
• Iceberg D-16, a 2006 city-sized iceberg near Antarctica
• two destroyers of the Royal Navy:
  • HMS Ivanhoe (D16)
  • HMS London (D16)
• USS Charrette (DD-581) renamed as the HHMS/HNS Velos (D-16)
• One of a number of railway locomotives:
  • British Rail Class D16/1, two experimental diesel locomotives of 1947/8
  • British Rail Class D16/2, three experimental diesel locomotives of 1950–54
  • GSR Class D16, a 1900 class of 4-4-0 on the Midland Great Western Railway, and later the Great Southern Railways
  • LNER Class D16, the London and North Eastern Railway classification of the Great Eastern Railway Class H88 "Super Claud" 4-4-0
  • PRR D16, an 1895 class of 4-4-0 on the Pennsylvania Railroad

and also :

• Honda D engine, when of 1.6 litre capacity
• Chondroma ICD-10 code
• Dublin 16, a Dublin, Ireland postal district

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