This article is about the street in Montreal called the rue Sainte-Catherine in French. For other streets of this name, see Rue Sainte-Catherine (disambiguation).

Sainte-Catherine Street (French: rue Sainte-Catherine) is the primary commercial artery of Downtown Montreal, Quebec, Canada. It crosses the central business district from west to east, beginning at the corner of Claremont Avenue and de Maisonneuve Boulevard in the city of Westmount, traversing the borough of Ville-Marie, and ending on Notre-Dame Street just east of Viau Street in the borough of Mercier–Hochelaga-Maisonneuve.

The street runs parallel to the largest segments of Montreal's underground city. The series of interconnected office tower basements and shopping complexes that make up this main thoroughfare lie immediately north of the street.

Educational institutions located on or near the street include Concordia University, McGill University, Université du Québec à Montréal, Dawson College and LaSalle College.

Saint Catherine Street still been home to many of Montreal's prominent department stores, including such former retailers as Eaton's, Morgan's, Simpson's and Dupuis Freres. Today, the Morgan's building is home to Hudson's Bay Company, which acquired Morgan's in 1960. The Simpson's building is now shared by the La Maison Simons department store and a multiplex cinema, while Eaton's was converted to the Complexe Les Ailes. Dupuis Frères, located further east at Saint Catherine and Saint Hubert, is now a shopping mall and office complex.