DNA polymerase eta (Pol η), is a protein that in humans is encoded by the POLH gene.
DNA polymerase eta is a eukaryotic DNA polymerase involved in the DNA repair by translesion synthesis. The gene encoding DNA polymerase eta is POLH, also known as XPV, because loss of this gene results in the disease xeroderma pigmentosum. Polymerase eta is particularly important for allowing accurate translesion synthesis of DNA damage resulting from ultraviolet radiation or UV.
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum.
Don't you cry, don't you look so sad
We both knew somehow this day would come
I know you want what is best for me
And I need to see you smile
From where I started off to where I am
It's a million miles, I can't go back there again
But no matter where I go from here
You will be part of me from now on
For every door that opens up
When another has to close
You got to trust me now
Be strong and let me go
Watch me now as I go my way
The time has come
And I gotta say I'm not afraid
Watch me now, every step I take
I feel stronger, so much stronger
The road ahead is a mystery
Your love is here
Oh and I believe inside of me
Watch me now, I can stand my ground
I will be alright, yes I'll be alright
You were someone who believed in me
When I wasn't even sure of myself
And I always will remember how
You were always there to help
And I heard so many things from you
And I'm ready now to try them out in the world
Though it hurts too much to say goodbye
We both know (We both know)
There's no other way
I will feel your loving arms
When I'm out there in the cold
'Cause all of my thoughts of you
Will still be mine to hold
Watch me now as I go my way
The time has come
And I gotta say I'm not afraid
Watch me now, every step I take
I feel stronger, so much stronger
The road ahead is a mystery
Your love is here
Oh and I believe inside of me
Watch me now, I can stand my ground
I will be alright, yes I'll be alright
You will find me running back sometime
When I really need a guiding hand
We'll be closer than we were before
And I know that you will understand
I know you'll understand
Watch me now as I go my way
The time has come
And I gotta say I'm not afraid
Watch me now, every step I take
I feel stronger, so much stronger
The road ahead is a mystery
Your love is here
Oh and I believe inside of me
Watch me now, I can stand my ground
I will be alright, yes I'll be alright