This is an audio version of the Wikipedia Article: https://en.wikipedia.org/wiki/Transcription_factor 00:01:44 1 Number 00:03:01 2 Mechanism 00:04:30 3 Function 00:05:03 3.1 Basal transcription regulation 00:05:52 3.2 Differential enhancement of transcription 00:06:23 3.2.1 Development 00:07:11 3.2.2 Response to intercellular signals 00:08:06 3.2.3 Response to environment 00:08:50 3.2.4 Cell cycle control 00:09:18 3.2.5 Pathogenesis 00:10:14 4 Regulation 00:10:54 4.1 Synthesis 00:11:42 4.2 Nuclear localization 00:12:23 4.3 Activation 00:13:14 4.4 Accessibility of DNA-binding site 00:14:32 4.5 Availability of other cofactors/transcription factors 00:15:56 5 Structure 00:17:12 5.1 Trans-activating domain 00:18:07 5.2 DNA-binding domain 00:18:30 5.3 Response elements 00:20:37 6 Clinical significance 00:20:59 6.1 Disorders 00:21:41 6.2 Potential drug targets 00:22:38 7 Role in evolution 00:23:36 8 Analysis 00:24:58 9 Classes 00:25:23 9.1 Mechanistic 00:26:18 9.2 Functional 00:27:58 9.3 Structural Listening is a more natural way of learning, when compared to reading. Written language only began at around 3200 BC, but spoken language has existed long ago. Learning by listening is a great way to: - increases imagination and understanding - improves your listening skills - improves your own spoken accent - learn while on the move - reduce eye strain Now learn the vast amount of general knowledge available on Wikipedia through audio (audio article). You could even learn subconsciously by playing the audio while you are sleeping! If you are planning to listen a lot, you could try using a bone conduction headphone, or a standard speaker instead of an earphone. Listen on Google Assistant through Extra Audio: https://assistant.google.com/services/invoke/uid/0000001a130b3f91 Other Wikipedia audio articles at: https://www.youtube.com/results?search_query=wikipedia+tts Upload your own Wikipedia articles through: https://github.com/nodef/wikipedia-tts Speaking Rate: 0.8430857445101478 Voice name: en-AU-Wavenet-B "I cannot teach anybody anything, I can only make them think." - Socrates SUMMARY ======= In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Groups of TFs function in a coordinated fashion to direct cell division, cell growth, and cell death throughout life; cell migration and organization (body plan) during embryonic development; and intermittently in response to signals from outside the cell, such as a hormone. There are up to 2600 TFs in the human genome. TFs work alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme that performs the transcription of genetic information from DNA to RNA) to specific genes.A defining feature of TFs is that they contain at least one DNA-binding domain (DBD), which attaches to a specific sequence of DNA adjacent to the genes that they regulate. TFs are grouped into classes based on their DBDs. Other proteins such as coactivators, chromatin remodelers, histone acetyltransferases, histone deacetylases, kinases, and methylases are also essential to gene regulation, but lack DNA-binding domains, and therefore are not TFs.TFs are of interest in medicine because TF mutations can cause specific diseases, and medications can be potentially targeted toward them.

• published: 10 May 2019
• views: 50