Édon

Édon is a commune in the Charente department in southwestern France.

Geography

The Lizonne (locally called Nizonne) forms the commune's southeastern border.

Population

See also

References

Regular Show (season 1)

The first season of American animated television series Regular Show originally aired on Cartoon Network in the United States. Many of the characters are loosely based on those developed for J.G. Quintel's student films at California Institute of the Arts: The Naïve Man From Lolliland and 2 in the AM PM. Quintel pitched Regular Show for Cartoon Network's Cartoonstitute project, in which the network allowed young artists to create pilots with no notes to possibly be optioned as a show. After being green-lit, Quintel recruited several indie comic book artists, plus some of the crewmembers he had worked with on The Marvelous Misadventures of Flapjack, to compose the staff of the show, as their style matched close to what he desired for the series. Regular Show was picked up by Cartoon Network, who decided to create a twelve-episode first season.

The first episode of Regular Show's first season is "The Power", ending with the season finale "Mordecai and the Rigbys". The season was storyboarded and written by J. G. Quintel, Sean Szeles, Shion Takeuchi, Mike Roth, Jake Armstrong, Benton Connor, Kat Morris, Paul Scarlata, and Kent Osborne, while being produced by Cartoon Network Studios. The show is rated TV-PG and occasionally TV-PG-V. Despite not airing on Cartoon Network's Adult Swim line-up, it is considered more of a traditional adult's animated comedy than a children's cartoon.

Don (franchise)

Don is an Indian action crime film, Comics and Video game franchise. The franchise is centered on Don, a fictional mafia lord played by Amitabh Bachchan and Shahrukh Khan in the films.

In the series Amitabh Bachchan stars in the first film and Shahrukh Khan in the rest of the films. After the release of Don 2, the latest installment of the series, it was considered to be one of the finest action film series in India along with Dhoom (film series) and Race (film series).

Don is now the fifth highest grossing film series in Bollywood.

Films

Production

Production for Don

Don't (Ed Sheeran song)

"Don't" is a song recorded by English singer-songwriter, Ed Sheeran, for his second studio album, × (2014). Written by Sheeran and Benny Blanco and produced by Blanco and Rick Rubin, the song samples "Don't Mess with My Man" by Lucy Pearl. It was initially planned as the album's lead single, but was passed over in favour of "Sing". It was instead released to iTunes on 13 June 2014 as the second "instant grat" promotional single from ×. "Don't" officially impacted US contemporary hit radio on 15 July 2014 and was released independently on 24 August 2014 as the album's second single.

"Don't" peaked at No. 8 on the UK Singles Chart. In the US, it became Sheeran's first top 10 single. It also made the top 10 in eight other countries.

Background and composition

The song developed from a riff, which Sheeran had on his phone for a year. Sheeran first recorded the track with producer, Benny Blanco, who was also credited as co-writer under his real name, Benjamin Levin. Sheeran recorded it again with Rick Rubin. The two producers coming together to produce the final cut. "Don't" has R&B and blue-eyed soul influences.

Twelve Angry Men

Twelve Angry Men is a drama written by Reginald Rose concerning the jury of a homicide trial. It was broadcast initially as a television play in 1954. The following year it was adapted for the stage, and in 1957 was made into a highly successful film. Since then it has been given numerous remakes, adaptations, and tributes.

Description

The play concerns the deliberations of the jury of a homicide trial. At the beginning, they have a nearly unanimous decision of guilty, with a single dissenter of not guilty, who throughout the play sows a seed of reasonable doubt. This was first made as a 1954 teleplay by Reginald Rose for the Studio One anthology television series, and was aired as a live CBS Television production on 20 September 1954. The drama was later rewritten for the stage in 1955 under the same title.

Stage

Rose wrote several stage adaptations of the story. In 1964, Leo Genn appeared in the play on the London stage. In other theatrical adaptations in which female actors are cast, the play is retitled 12 Angry Jurors, 12 Angry Men and Women or 12 Angry Women.

Two and a Half Men

Two and a Half Men is an American television sitcom that began broadcast on CBS on September 22, 2003 and ended on February 19, 2015 after twelve seasons. Originally starring Charlie Sheen, Jon Cryer, and Angus T. Jones, the show was about a hedonistic jingle writer, Charlie Harper; his uptight brother Alan; and Alan's son Jake. After Alan divorces, he moves with his son to share Charlie's beachfront Malibu house and complicate Charlie's freewheeling life.

In 2010, CBS and Warner Bros. Television reached a multi-year broadcast agreement for the series, renewing it through at least the 2011–12 season. But, on February 24, 2011, CBS and Warner Bros. decided to end production for the rest of the eighth season after Sheen entered drug rehabilitation and made "disparaging comments" about the show's creator and executive producer Chuck Lorre. Sheen's contract was terminated on March 7.

The ninth-season premiere, "Nice to Meet You, Walden Schmidt", killed off Sheen's character and introduced Ashton Kutcher as Walden Schmidt, his replacement. Alan is shown moving on with his life after the death of Charlie. He has a new best friend and housemate, Walden, who is dealing with his own troubles following a bad divorce. Walden, Alan, and Jake eventually bond, becoming close friends and forming a surrogate family unit. Jake, who joins the army at the end of season nine, leaves for Japan at the end of season ten.

MEN1

Menin is a protein that in humans is encoded by the MEN1 gene. Menin is a putative tumor suppressor associated with multiple endocrine neoplasia type 1 (MEN-1 syndrome).

In vitro studies have shown that menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD. However, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Two variants of the shorter transcript have been identified where alternative splicing affects the coding sequence. Five variants where alternative splicing takes place in the 5' UTR have also been identified.

History

In 1988, researchers at Uppsala University Hospital and the Karolinska Institute in Stockholm mapped the MEN1 gene to the long arm of chromosome 11. The gene was finally cloned in 1997.

Genomics

The gene is located on long arm of chromosome 11 (11q13) between base pairs 64,570,985 and 64,578,765. It has 10 exons and encodes a 610-amino acid protein.