- published: 30 Aug 2009
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Avram Hershko (Hebrew: אברהם הרשקו; born 31 December 1937) is a Hungarian-Israeli biochemist and Nobel laureate in Chemistry.
Born Herskó Ferenc in Karcag, Hungary, Hershko emigrated to Israel in 1950. Received his M.D. in 1965 and his Ph.D in 1969 from the Hebrew University-Hadassah Medical School, Jerusalem, Israel. He is currently a Distinguished Professor at the Rappaport Faculty of Medicine at the Technion in Haifa.
Along with Aaron Ciechanover and Irwin Rose, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation. The ubiquitin-proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as: cancer, muscular and neurological diseases, immune and inflammatory responses.
His contributions to science directly helped cure his long-time friend from cancer.
In 2005, he was voted the co-31st-greatest Israeli of all time, in a poll by the Israeli news website Ynet to determine whom the general public considered the 200 Greatest Israelis. Hershko's work and reception of the Nobel Prize is cited as a historic milestone in the unique history of the Technion - Israel Institute of Technology.