S100B
S100 calcium-binding protein B (S100B) is a protein of the S-100 protein family.
S100 proteins are localized in the cytoplasm and nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3.
Function
S100B is glial-specific and is expressed primarily by astrocytes, but not all astrocytes express S100B. It has been shown that S100B is only expressed by a subtype of mature astrocytes that ensheath blood vessels and by NG2-expressing cells.
This protein may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. In the developing CNS it acts as a neurotrophic factor and neuronal survival protein. In the adult organism it is usually elevated due to nervous system damage, which makes it a potential clinical marker.
S. O. S.
Where are those happy days, they seem so hard to find
I tried to reach for you, but you have closed your mind
Whatever happened to our love
I wish I understood
It used to be so nice, it used to be so good
So when you're near me, darling can't you hear me
S. O. S.
The love you gave me, nothing else can save me
S. O. S.
When you're gone
How can I even try to go on
When you're gone
Though I try how can I carry on
You seem so far away though you are standing near
You made me feel alive, but something died I fear
I really tried to make it out
I wish I understood
What happened to our love, it used to be so good
So when you're near me, darling can't you hear me
S. O. S.
The love you gave me, nothing else can save me
S. O. S.
When you're gone
How can I even try to go on
When you're gone
Though I try how can I carry on
So when you're near me, darling can't you hear me
S. O. S.
And the love you gave me, nothing else can save me
S. O. S.
When you're gone
How can I even try to go on
When you're gone
Though I try how can I carry on
When you're gone
How can I even try to go on
When you're gone
Though I try how can I carry on