7-Chlorokynurenic acid

7-Chlorokynurenic acid (7-CKA) is a drug that acts as a potent and selective noncompetitive antagonist of the glycine site of the NMDA receptor. It produces ketamine-like rapid antidepressant effects in animal models of depression. However, 7-CKA is unable to cross the blood-brain-barrier, and for this reason, is unsuitable for clinical use. As a result, a centrally-penetrant prodrug of 7-CKA, 4-chlorokynurenine (AV-101), has been developed for use in humans, and is being studied in clinical trials as a potential treatment for major depressive disorder. In addition to antagonizing the NMDA receptor, 7-CKA also acts as a potent inhibitor of the reuptake of glutamate into synaptic vesicles (or as a vesicular glutamate reuptake inhibitor), an action that it mediates via competitive blockade of vesicular glutamate transporters (K_i = 0.59 mM).

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Leaf Rapids Water Aerodrome

Leaf Rapids Water Aerodrome, (TC LID: CKA3), is located 5 nautical miles (9.3 km; 5.8 mi) north of Leaf Rapids, Manitoba, Canada.

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Zhoda Airport

Zhoda Airport, (TC LID: CKA4), is located adjacent to Zhoda, Manitoba, Canada.

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