The Cleveland Clinic (formally known as the Cleveland Clinic Foundation) is a multispecialty academic medical center located in Cleveland, Ohio, United States. The Cleveland Clinic is currently regarded as one of the top 4 hospitals in the United States as rated by U.S. News & World Report. The Cleveland Clinic was established in 1921 by four physicians for the purpose of providing patient care, research, and medical education in an ideal medical setting. One of the largest private medical centers in the world, the Cleveland Clinic saw more than 3,200,000 patient visits in 2009, with almost 80,000 hospital admissions. Patients arrive at the Cleveland Clinic from all 50 states and more than 100 nations. The Cleveland Clinic's approximately 2,500 staff physicians and residents represent 120 medical specialties and subspecialties. The Cleveland Clinic was ranked number one in America for cardiac care from 1994 to 2009.

Cleveland Clinic is also an Ohio nonprofit corporation which as of December 2010 had 10 regional hospitals in Northeast Ohio, a hospital and family health center in Florida, and a health center in Toronto, Ontario, Canada, a specialty center in Las Vegas, and a hospital in Abu Dhabi opening in 2012.

Cleveland ( /ˈkliːvlənd/) is a city in the U.S. state of Ohio and is the county seat of Cuyahoga County, the most populous county in the state. The city is located in northeastern Ohio on the southern shore of Lake Erie, approximately 60 miles (97 km) west of the Pennsylvania border. It was founded in 1796 near the mouth of the Cuyahoga River, and became a manufacturing center owing to its location on the lake shore, as well as being connected to numerous canals and railroad lines. Cleveland's economy has diversified sectors that include manufacturing, financial services, healthcare, and biomedical. Cleveland is home to the Rock and Roll Hall of Fame.

As of the 2010 Census, the city proper had a total population of 396,815 and was the 45th largest city in the United States, and the second largest city in Ohio. It is the center of Greater Cleveland, the largest metropolitan area in Ohio. The Cleveland-Elyria-Mentor Metropolitan Statistical Area in 2011 ranked as the 28th largest in the United States with 2,068,283 people. Cleveland is part of the larger Cleveland-Akron-Elyria Combined Statistical Area, which in 2011 had a population of 2,871,084, and ranked as the country's 15th largest.