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Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma

PNAS 23 Feb 2015
Here we report a cancer-specific gene fusion between BCAM, a membrane adhesion molecule, and AKT2, a key kinase in the PI3K signaling pathway ... Further, we provide direct evidence that BCAM-AKT2 is translated into an in-frame fusion protein in the patient’s tumor. The resulting AKT2 ...
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Russian President Vladimir Putin during a meeting of the Supreme Eurasian Economic Council (via videoconference), May 27, 2022 the Kremlin, Moscow, Russia.
Russian Presidential Press and Information Office
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AP / Marlon Costa/Futura Press
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