MDK

MDK may refer to:

Entertainment

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Midkine

Midkine (MK or MDK) also known as neurite growth-promoting factor 2 (NEGF2) is a protein that in humans is encoded by the MDK gene.

Midkine is a basic heparin-binding growth factor of low molecular weight, and forms a family with pleiotrophin (NEGF1, 46% homologous with MK). It is a nonglycosylated protein, composed of two domains held by disulfide bridges. It is a developmentally important retinoic acid-responsive gene product strongly induced during mid-gestation, hence the name midkine. Restricted mainly to certain tissues in the normal adult, it is strongly induced during oncogenesis, inflammation and tissue repair.

MK is pleiotropic, capable of exerting activities such as cell proliferation, cell migration, angiogenesis and fibrinolysis. A molecular complex containing receptor-type tyrosine phosphatase zeta (PTPζ), low density lipoprotein receptor-related protein (LRP1), anaplastic leukemia kinase (ALK) and syndecans is considered to be its receptor.

Role in cancer

MK appears to enhance the angiogenic and proliferative activities of cancer cells. The expression of MK (mRNA and protein expression) has been found to be elevated in multiple cancer types, such as neuroblastoma, glioblastoma, Wilms’ tumors, thyroid papillary carcinomas, colorectal, liver, ovary, bladder, breast, lung, esophageal, stomach, and prostate cancers. Serum MK in normal individuals is usually less than 0.5-0.6 ng/ml, whereas patients with these malignancies have much higher levels than this. In some cases, these elevated levels of MK also indicate a poorer prognosis of the disease, such as in neuroblastoma, gliablastoma, and bladder carcinomas. In neuroblastoma, for example, the levels of MK are elevated about three times the level in Stage 4 of the cancer (one of the final stages) than they are in Stage 1.

HIStory: Past, Present and Future, Book I

HIStory: Past, Present and Future, Book I (usually shortened to HIStory) is the ninth overall studio album and his fifth under Epic Records by American recording artist Michael Jackson. It was released on June 16, 1995 by Epic Records. This is Jackson's first album on his own label, MJJ Productions, and consists of two discs: the first disc (HIStory Begins) is a compilation of some of his greatest hits from 1979 onward, while the second disc (HIStory Continues) is a studio album composed entirely of new material. The majority of the second disc's tracks were written and produced by Jackson, often in conjunction with collaborators.

HIStory was Jackson's return to releasing music following the accusation of child sexual abuse in August 1993. Many of the 15 songs pertain to the accusations and Jackson's mistreatment in the media, specifically the tabloids. The songs' themes include environmental awareness, isolation, greed, suicide and injustice.

HIStory is Jackson's most controversial album. Jackson was accused of using anti-Semitic lyrics in "They Don't Care About Us". Jackson stated that he did not mean any offense and on multiple occasions denied anti-Semitism. The dispute regarding the lyrics ended with Jackson re-recording them. R. Kelly was accused of plagiarizing one of the album's songs, "You Are Not Alone". In 2007 a judge ruled that the song was plagiarized and the song was subsequently banned from radio stations in Belgium.

Money (Blackadder)

"Money" is the fourth episode of the BBC sitcom Blackadder II, the second series of Blackadder, which was set in Elizabethan England from 1558 to 1603.

Plot

Blackadder owes one thousand pounds to the Bishop of Bath and Wells, who threatens to have him killed if he does not pay. Blackadder tries unsuccessfully to blackmail the Bishop. He has only 85 pounds, which he loses when the Queen wins a bet about him with Lord Melchett.

Blackadder and Baldrick manage to get sixpence from a sailor, which is also taken by the Queen. Lord Percy tries to make them money by alchemy, without success, only producing a green substance, which he seems convinced is valuable. Blackadder manages to bully a couple into buying his house for 1100 pounds, but is again tricked out of the money by the Queen.

Finally, Blackadder drugs the Bishop and has a painting made of him in a highly compromising position. He uses this to successfully blackmail the Bishop into writing off the debt and giving him enough money to buy back his house and live in comfort. The Bishop is impressed by his treachery, but asks who the other figure in the painting is, at which Blackadder reveals Percy.

Money (KMFDM song)

"Money" is a song by industrial rock group KMFDM from their 1992 album of the same name. It was released as a single in 1992, and released as a 7" in 2008, as the ninth release of KMFDM's 24/7 series. The song charted at No. 36 in July 1992 on Billboard's Dance/Club Play Songs Chart.

Track listing

1992 release

2008 7" reissue

Personnel

References