MDK

MDK may refer to:

Entertainment

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Midkine

Midkine (MK or MDK) also known as neurite growth-promoting factor 2 (NEGF2) is a protein that in humans is encoded by the MDK gene.

Midkine is a basic heparin-binding growth factor of low molecular weight, and forms a family with pleiotrophin (NEGF1, 46% homologous with MK). It is a nonglycosylated protein, composed of two domains held by disulfide bridges. It is a developmentally important retinoic acid-responsive gene product strongly induced during mid-gestation, hence the name midkine. Restricted mainly to certain tissues in the normal adult, it is strongly induced during oncogenesis, inflammation and tissue repair.

MK is pleiotropic, capable of exerting activities such as cell proliferation, cell migration, angiogenesis and fibrinolysis. A molecular complex containing receptor-type tyrosine phosphatase zeta (PTPζ), low density lipoprotein receptor-related protein (LRP1), anaplastic leukemia kinase (ALK) and syndecans is considered to be its receptor.

Role in cancer

MK appears to enhance the angiogenic and proliferative activities of cancer cells. The expression of MK (mRNA and protein expression) has been found to be elevated in multiple cancer types, such as neuroblastoma, glioblastoma, Wilms’ tumors, thyroid papillary carcinomas, colorectal, liver, ovary, bladder, breast, lung, esophageal, stomach, and prostate cancers. Serum MK in normal individuals is usually less than 0.5-0.6 ng/ml, whereas patients with these malignancies have much higher levels than this. In some cases, these elevated levels of MK also indicate a poorer prognosis of the disease, such as in neuroblastoma, gliablastoma, and bladder carcinomas. In neuroblastoma, for example, the levels of MK are elevated about three times the level in Stage 4 of the cancer (one of the final stages) than they are in Stage 1.

Reality (David Bowie album)

Reality is the twenty-third studio album by English rock musician David Bowie. It was released in 2003 on his Iso Records label, in conjunction with Columbia Records.

Recording and production

The album was recorded and produced in New York's Looking Glass Studios and co-produced by Bowie and Tony Visconti. Consisting mostly of original compositions, the album also includes two cover songs, The Modern Lovers' "Pablo Picasso" and George Harrison's "Try Some, Buy Some". These two tracks were originally slated for Bowie's never-recorded Pin Ups 2 album from the early 1970s.

Bowie started writing the songs for Reality as the production for his previous album Heathen was wrapping up. Some songs he wrote quickly: "Fall Dog Bombs the Moon" was written in 30 minutes. Other songs, such as "Bring Me the Disco King", was a song Bowie had tried his hand at as early as the 1970s and had tried again with 1993's Black Tie White Noise as well as Heathen in 2002.

Bowie and Visconti produced both the stereo and 5.1 mix in the studio as the album was recorded.

Days (The Kinks song)

"Days" is a song by The Kinks, written by lead singer Ray Davies, released as a single in 1968. It also appeared on an early version of the album The Kinks Are the Village Green Preservation Society (released only in continental Europe and New Zealand), and now appears as a bonus track of the remastered CD. On the original Pye 7N 17573 label, the name of the song is "Day's".

Release and reception

The song was an important single for Davies and the Kinks, coming in a year of declining commercial fortunes for the band. The song had been intended as an album track but after the relative failure of the previous single "Wonderboy" (which only reached No. 36 in the UK), "Days" was rushed out as a single with an old unreleased track "She's Got Everything" (recorded in February 1966 in the same session as "Dedicated Follower of Fashion") as the B-side. It reached No. 12 on the UK chart, but failed to chart in the U.S. This did not help future releases however as the next four Kinks singles failed to reach the top 30 (two of them failing to chart altogether) in the UK.

Days (Alisa Mizuki song)

"Days" is the fourteenth single by Japanese recording artist Alisa Mizuki. It was released on November 19, 1997 as the fifth and final single from Mizuki's third compilation album Fiore II. It was also included on Mizuki's fifth studio album Innocence. The title track was written and produced by former Every Little Thing keyboardist Mitsuru Igarashi and served as theme song for the second season of the Fuji TV drama Nurse no Oshigoto, starring Mizuki herself. "Days" is Mizuki's first release under the record label Avex Tune.

Chart performance

"Days" debuted on the Oricon Weekly Singles chart at number 14 with 28,020 copies sold in its first week. It stayed in the top 30, at number 24, on its second week, with 18,660 copies sold. The single charted for nine weeks and has sold a total of 101,120 copies.

Track listing

Charts and sales

References