Interferon beta 1b

Interferon beta 1b is a cytokine in the interferon family used to treat the relapsing-remitting and secondary-progressive forms of multiple sclerosis (MS). It is approved for use after the first MS event. It is administered by sub-cutaneous injection and has been advertised as a way to slow the advance of the affliction as well as reduce the frequency of attacks. Closely related is interferon beta 1a, also indicated for MS, and with a very similar drug profile.

The assertion that interferon beta in either form can slow the advance of disability in multiple sclerosis is still unproven.

Mechanism of action

Interferon beta balances the expression of pro- and anti-inflammatory agents in the brain, and reduces the number of inflammatory cells that cross the blood brain barrier. Overall, therapy with interferon beta leads to a reduction of neuron inflammation. Moreover, it is also thought to increase the production of nerve growth factor and consequently improve neuronal survival.