- published: 02 Jan 2015
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Coordinates: 51°12′26″N 2°39′07″W / 51.2073°N 2.6519°W / 51.2073; -2.6519
Wells is a cathedral city and civil parish in the Mendip district of Somerset, England, on the southern edge of the Mendip Hills. Although the population recorded in the 2001 census is 10,406, it has had city status since 1205. It is the second smallest English city in terms of area and population after the City of London although, unlike the latter, Wells is not part of a larger metropolitan conurbation, and is consequently described in some sources as being England's smallest city.
The name Wells derives from the three wells dedicated to Saint Andrew, one in the market place and two within the grounds of the Bishop's Palace and cathedral. There was a small Roman settlement around the wells, but its importance grew under the Saxons when King Ine of Wessex founded a minster church in 704, around which the settlement grew. Wells became a trading centre and involved in cloth making before its involvement in both the English Civil War and the Monmouth Rebellion during the 17th century. In the 19th century, transport infrastructure improved with stations on three different railway lines.
George Wells Beadle (October 22, 1903 – June 9, 1989) was an American scientist in the field of genetics, and Nobel Prize in Physiology or Medicine Nobel laureate who with Edward Lawrie Tatum discovered the role of genes in regulating biochemical events within cells.
Beadle and Tatum's key experiments involved exposing the bread mold Neurospora crassa to x-rays, causing mutations. In a series of experiments, they showed that these mutations caused changes in specific enzymes involved in metabolic pathways. These experiments led them to propose a direct link between genes and enzymatic reactions, known as the "one gene, one enzyme" hypothesis.
George Wells Beadle was born in Wahoo, Nebraska. He was the son of Chauncey Elmer Beadle and Hattie Albro, who owned and operated a 40-acre (160,000 m2) farm nearby. George was educated at the Wahoo High School and might himself have become a farmer if one of his teachers at school had not directed his mind towards science and persuaded him to go to the College of Agriculture in Lincoln, Nebraska. In 1926 he took his B.Sc. degree at the University of Nebraska and subsequently worked for a year with Professor F.D. Keim, who was studying hybrid wheat. In 1927 he took his M.Sc. degree, and Professor Keim secured for him a post as Teaching Assistant at Cornell University, where he worked, until 1931, with Professors R.A. Emerson and L.W. Sharp on Mendelian asynopsis in Zea mays. For this work he obtained, in 1931, his Ph.D. degree. In 1931 he was awarded a National Research Council Fellowship at the California Institute of Technology at Pasadena, where he remained from 1931 until 1936. During this period he continued his work on Indian corn and began, in collaboration with Professors Th. Dobzhansky, S. Emerson, and A.H. Sturtevant, work on crossing-over in the fruit fly, Drosophila melanogaster.