Isa Yusuf Alptekin or ʿĪsa Yūsuf Alptekin (Uyghur: عيسى يوسف آلبتكين‎ Айсабек (known in China as Ai Sha, Chinese: 艾沙伯克; pinyin: àishābókè) Chinese: 艾萨·玉素甫·阿布甫泰肯; pinyin: Àishā Yóushūfū Ābùtàijīn; 1901 – 17 December 1995) was a Uyghur political leader, exiled from China in 1949.

He was born at 1901 in Yengisar County, Kashgar, Qing Dynasty. He headed the First East Turkestan Republic in Kashgar from November 12, 1933 to February 6, 1934 as the General Secretary of the National Assembly of the Republic, alongside Prime Minister Sabit Damulla, and titular President Hoja-Niyaz. He also represented Eastern Turkestan in Nanjing from 1932 to 1934. Initially the republic was named the "Turkish Islamic Republic of East Turkestan" (TIRET), representing the multi-national staff of its government, which included Uyghurs, Kazakhs and Kyrgyz; its anti-Hui, anti-Han, and anti-communist policies, declared in its Declaration of Independence; and basic Islamic principles, declared in its constitution. Later, however, some leaders attempted to rename it as the "Republic of Uyghurstan", which resulted in the issuing of national currency in the form of minted copper (pul), silver (tanga), and gold (tilla) coins under the name Uyghurstan Jumhuriyeti.