In England, regional ministers were appointed from 2007 on a part-time basis as part of the Government of the United Kingdom. Each minister had other departmental responsibilities, as well as specific responsibilities for one of the English regions. Their stated role was "to provide a clear sense of strategic direction for the nine English regions and to help strengthen their links with central government."

Following the 2010 General Election, the Prime Minister's Spokesman was asked on 17 May 2010 if Regional Ministers had been scrapped. He said that the process of completing appointments to the Government was continuing, and that the Prime Minister, David Cameron, "had been very clear on the importance of devolution". On 4 June 2010 the Evening Standard reported that the post of Minister for London had been scrapped. No formal announcements were made in relation to regional ministers, but as of October 2010 no appointments had been made by the coalition government.

Regional ministers in England were first appointed by the incoming Prime Minister, Gordon Brown, on 28 June 2007, as part of his initial Government reshuffle. At the time, his spokesman said that their role would be "to act as regional champions within government, and to represent the government in parliamentary debates and other forums on regional issues."