Šiba

Šiba is a village and municipality in Bardejov District in the Prešov Region of north-east Slovakia.

History

In historical records the village was first mentioned in 1427.

Geography

The municipality lies at an altitude of 400 metres and covers an area of 13.825 km². It has a population of about 570 people.

External links

Coordinates: 49°14′N 21°14′E / 49.233°N 21.233°E / 49.233; 21.233

IBA

IBA or iba may refer to:

Iba

IBA

AIF1

Allograft inflammatory factor 1 (AIF-1) also known as ionized calcium-binding adapter molecule 1 (IBA1) is a protein that in humans is encoded by the AIF1 gene.

Gene

The AIF1 gene is located within a segment of the major histocompatibility complex class III region. It has been shown that this gene is highly expressed in testis and spleen, but weakly expressed in brain, lung, and kidney. Among brain cells, the Iba1 gene was specifically expressed in microglia. Upon activation of microglia due to inflammation, expression of Iba1 is upregulated allowing the discrimination between surveiling and activated microglia.

Function

AIF1 is a protein that exists in the cytoplasm, and it is highly evolutionarily conserved. It is also possibly identical to three other proteins, Iba-1, MRF-1 (microglia response factor) and daintain. However complete functional profiles of all three proteins and how they overlap is unknown. IBA1 is a 17-kDa EF hand protein that is specifically expressed in macrophages / microglia and is upregulated during the activation of these cells. Iba1 expression is up-regulated in microglia following nerve injury, central nervous system ischemia, and several other brain diseases.