Celebrity Rehab with Dr. Drew is a reality television show airing on the cable network VH1 that chronicles a group of celebrities as they are treated for alcohol and drug addiction by Dr. Drew Pinsky and his staff at the Pasadena Recovery Center in Pasadena, California. The first season premiered on January 10, 2008. Pinsky is listed in the show's onscreen credits as the executive producer.

The following are staff of the Pasadena Recovery Center (PRC), where the series is filmed. Casts for individual seasons are seen in sections for those seasons.

According to a December 2009 New York Times article, Drew Pinsky, who was alarmed by tabloid portrayals of addiction as an indulgence of the rich and famous, and a group of independent producers, approached VH1 with a proposal for a reality television series that would authentically depict addiction, as a sort of media intervention.

According to executive producer John Irwin, casting for the first season was the most difficult, as the representatives of the celebrities who had been arrested or had publicized bouts with addiction refused to speak with him and the other producers. The process became easier after the first season aired. Actor Tom Sizemore, for example, who was cast for Season 3, had been sought after since Season 1. Producers have reportedly offered actress Lindsay Lohan six figures to appear on the show. Pinsky, who focuses on the treatment side of the production, is not usually involved with casting, though he reportedly visited Rachel Uchitel personally in order to convince her to join the fourth season cast.

Daniel Leroy Baldwin (born October 5, 1960) is an American actor, producer and director. He is the second oldest of the four Baldwin brothers, all of whom are actors. Daniel Baldwin is known for his role as Detective Beau Felton in the popular NBC TV series Homicide: Life on the Street. Other films of his include Ned Blessing: The True Story of My Life (1992), Mulholland Falls (1996), Vampires (1998), The Pandora Project (1998), Stealing Candy (2002), Paparazzi (2004), and Grey Gardens (2009).

Baldwin was born in Massapequa, New York, the son of Carol Newcomb (née Martineau), a breast cancer survivor who founded the Carol M. Baldwin Breast Care Center of the University Hospital and Medical Center at Stony Brook, and Alexander Rae Baldwin, Jr., a high school history/social studies teacher and football coach. Baldwin was raised in a Catholic family of Irish, English, and French descent. In addition to his three famous actor brothers, Alec (born 1958), William (born 1963) and Stephen (born 1966), Baldwin has two sisters, Beth Baldwin Keuchler (born 1955), and Jane Baldwin Sasso (born 1965).

Layne Thomas Staley (August 22, 1967 – April 5, 2002) was an American musician who served as the lead singer and co-lyricist of the rock band Alice in Chains, which was formed in Seattle, Washington in 1987 by Staley and guitarist Jerry Cantrell. Alice in Chains rose to international fame as part of the grunge movement of the early 1990s. The band became known for his distinct vocal style, as well as the harmonized vocals between him and Cantrell. Staley was also a member of the supergroups Mad Season and Class of '99. He struggled throughout his career with severe drug addiction, culminating with his death in April 2002.

Layne Staley was born to Phil Staley and Nancy Staley (née McCallum) in Kirkland, Washington. He was seven years old when his parents divorced, after which he was raised by his mother and stepfather, Jim Elmer. He was raised Catholic. He took his stepfather's name while enrolled in Meadowdale High School and was known for some time as Layne Elmer. In early 2002, shortly before his death, he would describe the experience of witnessing his parents' divorce: "My world became a nightmare, there were just shadows around me. I got a call saying that my dad had died, but my family always knew he was around doing all kinds of drugs. Since that call I always was wondering, 'Where is my dad?' I felt so sad for him and I missed him. He dropped out of my life for 15 years." In that same interview he hinted that his parents' break-up and his father's drug use were at least partially responsible for his own drug problems, and also said that he was convinced that if he became a celebrity his dad would return.

Kari Ann Peniche (pronounced /pɛˈniːtʃeɪ/ pe-NEE-chay) (born March 20, 1984) is a former beauty queen and entertainer from Fairview, Oregon. She has held the Miss Oregon Teen USA and Miss United States Teen titles. She was stripped of the latter title after appearing nude in the November 2004 issue of Playboy magazine.

Peniche lived in San Diego before moving to Houston and then Oregon with her mother. She first attended a modeling class at age 12, and modeled in South Korea at ages 16 and 18. Since her Playboy pictorial, she has launched a fashion business, and has appeared on television and in movies. She has been the subject of several celebrity gossip stories, including a brief engagement to singer Aaron Carter, a quarrel with singer Mindy McCready, and the leak of a controversial home video involving actors Eric Dane and Rebecca Gayheart. She is also well known to television audiences for her appearances on the first season of Sex Rehab with Dr. Drew, the third season of Celebrity Rehab, and a brief appearance on the second season of Sober House.

Mackenzie Phillips (born November 10, 1959) is an American actress and singer best known for her roles in American Graffiti and as rebellious teenager Julie Cooper Horvath on the sitcom One Day at a Time. She's also known for her role in the Disney Channel science fiction show So Weird.

Born Laura Mackenzie Phillips in Alexandria, Virginia, she is the daughter of John Phillips, singer of The Mamas & the Papas, and his first wife, Susan Adams. She is the sister of Jeffrey Phillips and a half-sister of Tamerlane Phillips, actress Bijou Phillips, and singer Chynna Phillips.

Phillips attended Highland Hall Waldorf School in Northridge, California. At age 12, Phillips formed a band with three of her classmates and was spotted by a casting agent during one of their performances. She was given an audition for a role in the 1973 hit film American Graffiti, which she won.

Phillips was 12 when the filming of American Graffiti began, and 14 when the movie was released. She was cast as Carol Morrison, a young girl accidentally picked up by hot rodding teenager John Milner. Because of California state law, producer Gary Kurtz became Phillips' legal guardian during the filming.