Hugo

Hugo or HUGO may refer to:

People

Places

HUGO

Other uses

Hugo (video game)

There are several Hugo video games based on early episodes of Interactive Television Entertainment's TV show Hugo, part of the international Hugo franchise. From 1992 to 2000, ITE developed and released versions for Amiga, Commodore 64 and PC, as well as the Game Boy and PlayStation consoles, exclusively for European markets. In 2011, Krea Media published a series of mobile game remakes for Android.

The games resemble those on the television show; in almost all of them, the player guides the titular protagonist (a small, friendly troll named Hugo) to save his wife and children from the evil witch Scylla. To rescue his family, Hugo must navigate safely through dangerous environments in various minigame scenarios.

History

Two Amiga games, Hugo (originally titled Hugo - På Nye Eventyr: Del 1) and its sequel, Hugo 2 (originally Hugo - På Nye Eventyr: Del 2) were released in 1992. These were re-released as a 1994 compilation, Hugo (Hugo På Nye Eventyr), and ported to the PC in 1995-1996. Both games were similar to the TV show where the contestant would try to completes arcade sequences to collect points and avoid obstacles using a phone, and the ending minigames are identical. Later PC releases included Hugo 3 to Hugo 6, Hugo: Wild River (1998), and their upgraded compilations Hugo Gold (1998), Hugo Platin (1999) and Hugo XL (1999).

Hugo: Man of a Thousand Faces

Hugo: Man of a Thousand Faces, was a lifelike doll produced by Kenner toy company in 1975. It included many accessories, such as goatee and sideburns, which could be glued onto his bald head, creating a variety of looks. Hugo has since become a highly sought-after toy on the collector's market.

About

Hugo was created by Alan Ormsby and produced by Kenner toy company in 1975. The Hugo doll featured lifelike facial characteristics, and came with a makeup kit, wig, glasses, and several different glue-on accessories. He was housed in a large box showing him in different disguises, and had a soft rubber head and plastic hard hands. His arms were stuffed with cotton wool - international variants having plastic arms.

Collector's Market

Hugo has become a highly sought-after toy on the collector's market, especially on sites such as eBay.

Finding a set with all the accessories is difficult, since the special nontoxic glue (as stated in the instruction booklet) used to stick his disguises is usually dry after the time passed. Both the Kenner and Denys fisher boxes are identical except for the logos of each of the toy companies.

Proposed top-level domain

The Domain Name System of the Internet consists of a set of top-level domains which constitute the root domain of the hierarchical name space and database. In the growth of the Internet, it became desirable to expand the set of initially six generic top-level domains in 1984. As a result new top-level domain names have been proposed for implementation by ICANN. Such proposals included a variety of models ranging from adoption of policies for unrestricted gTLDs that could be registered by anyone for any purpose, to chartered gTLDs for specialized uses by specialized organizations. In October 2000, ICANN published a list of proposals for top-level domain strings it had received.

Geographic proposals

MED28

Mediator of RNA polymerase II transcription subunit 28 is an enzyme that in humans is encoded by the MED28 gene. It forms part of the Mediator complex.

Function

Subunit Med28 of the Mediator may function as a scaffolding protein within Mediator by maintaining the stability of a submodule within the head module, and components of this submodule act together in a gene-regulatory programme to suppress smooth muscle cell differentiation. Thus, mammalian Mediator subunit Med28 functions as a repressor of smooth muscle-cell differentiation, which could have implications for disorders associated with abnormalities in smooth muscle cell growth and differentiation, including atherosclerosis, asthma, hypertension, and smooth muscle tumours.

Interactions

MED28 has been shown to interact with Merlin,Grb2 and MED26.

See also

References

This article incorporates text from the public domain Pfam and InterPro IPR021640

Further reading

MED1

Mediator of RNA polymerase II transcription subunit 1 also known as DRIP205 or Trap220 is a subunit of the Mediator complex and is a protein that in humans is encoded by the MED1 gene. MED1 functions as a nuclear receptor coactivator.

Function

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The mediator of RNA polymerase II transcription subunit 1 protein is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes [e.g., thyroid hormone receptor-(TR-) associated proteins that interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors]. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize.