Madden NFL 06 is an American football video game which was released on August 8, 2005. It is also a launch game for the Xbox 360. It is the 16th installment of the Madden NFL series by EA Sports, named for noted color commentator John Madden. The product features former Philadelphia Eagles quarterback Donovan McNabb on the cover. It is the first Madden game for the PlayStation Portable and Xbox 360.

One of the additions to the 2006 version of Madden is Superstar mode, which allows the player to create and take control of an NFL player from his rookie year all the way to retirement. An athlete can be created by evaluating pairs of parents — judging, based on their IQs, occupations, and hobbies, whether their child would excel in the NFL — or by importing a player from NCAA Football 06 or NFL Street 2. This player is 21 years old at the start of his career. Superstar mode is essentially Madden's Franchise mode seen through the eyes of this athlete. Rather than manage the team's front office, the player manages the career of his athlete: selecting movie roles, accepting product endorsement, etc. The player can access different areas of the city the Superstar is playing in such as the barber shop, to get a haircut or the performance institute to raise attributes if the player's agent has a key. As the player gains in popularity and prestige the superstar's home will transform from an apartment to a luxurious mansion. The player will receive calls from former NFL running back Terrell Davis, who is the player's mentor and guide. This addition has met with mixed reviews from video game reviewers. Although the idea is considered great in concept, many found the actual execution of the mode to be lackluster.

Madden NFL (known as John Madden Football before 1993) is an American football video game series developed by Electronic Arts Tiburon for EA Sports. The game series is named after Pro Football Hall of Famer John Madden, a well-known former Super Bowl–winning coach of the Oakland Raiders and color commentator. The games have consistently been a best seller, and has even spawned TV shows where players compete. Among the game's realistic features include sophisticated playbooks and player statistics, and voice commentary that allows players to hear the game as if it were a real TV broadcast.

The series was originally conceived by Electronic Arts founder Trip Hawkins, who then approached Madden in 1984 for his endorsement and expertise. Due to Madden's insistence that the game be as realistic as possible, the first version of John Madden Football was not released until 1988. The second version of the game was released in 1990, with annual versions since then. The series' name was changed to Madden NFL in 1993 after EA acquired the rights to use NFL teams and players. Despite Madden's retirement as a broadcaster in 2009, he continues to lend his name and provide expertise for the game.